PROCR binds Protein C

Stable Identifier
R-HSA-5591052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
EPCR binds Protein C
ReviewStatus
5/5
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PROCR binds Protein C
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Physiological activation of protein C on the endothelial cell surface requires the binding of protein C to the endothelial protein C receptor PROCR (EPCR) as well as binding of thrombin to thrombomodulin (TM) (Stavenuiter et al. 2013). PROCR binding to protein C (Fukudome & Esmon 1994) augments by at least 5-fold the effect of thrombin-thrombomodulin on the rate of protein C activation (Stearns-Kurosawa et al. 1996, Taylor et al. 2001).
Literature References
PubMed ID Title Journal Year
11238108 Endothelial cell protein C receptor plays an important role in protein C activation in vivo

Ferrell, G, Lockhart, MS, Esmon, CT, Peer, GT, Taylor, FB

Blood 2001
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
PROCR(18-?):Activated protein C [extracellular region] (Homo sapiens)
Orthologous Events
PROCR binds Protein C (Bos taurus)
PROCR binds Protein C (Canis familiaris)
PROCR binds Protein C (Gallus gallus)
PROCR binds Protein C (Mus musculus)
PROCR binds Protein C (Rattus norvegicus)
PROCR binds Protein C (Sus scrofa)
Authored
Jupe, S  (2014-07-14)
Reviewed
Mumford, D  (2014-09-11)
Created
Jupe, S  (2014-06-11)
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