PROCR binds Protein C

Stable Identifier
R-HSA-5591052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Synonyms
EPCR binds Protein C
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PROCR binds Protein C
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Physiological activation of protein C on the endothelial cell surface requires the binding of protein C to the endothelial protein C receptor PROCR (EPCR) as well as binding of thrombin to thrombomodulin (TM) (Stavenuiter et al. 2013). PROCR binding to protein C (Fukudome & Esmon 1994) augments by at least 5-fold the effect of thrombin-thrombomodulin on the rate of protein C activation (Stearns-Kurosawa et al. 1996, Taylor et al. 2001).

Literature References
PubMed ID Title Journal Year
11238108 Endothelial cell protein C receptor plays an important role in protein C activation in vivo

Taylor, FB, Peer, GT, Lockhart, MS, Ferrell, G, Esmon, CT

Blood 2001
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Negatively by
Orthologous Events
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Authored
Jupe, S  (2014-07-14)
Reviewed
Mumford, D  (2014-09-11)
Created
Jupe, S  (2014-06-11)