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PROCR binds Protein C
Stable Identifier
R-HSA-5591052
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
Synonyms
EPCR binds Protein C
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
PROCR binds Protein C (Homo sapiens)
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Physiological activation of protein C on the endothelial cell surface requires the binding of protein C to the endothelial protein C receptor PROCR (EPCR) as well as binding of thrombin to thrombomodulin (TM) (Stavenuiter et al. 2013). PROCR binding to protein C (Fukudome & Esmon 1994) augments by at least 5-fold the effect of thrombin-thrombomodulin on the rate of protein C activation (Stearns-Kurosawa et al. 1996, Taylor et al. 2001).
Literature References
PubMed ID
Title
Journal
Year
11238108
Endothelial cell protein C receptor plays an important role in protein C activation in vivo
Ferrell, G
,
Lockhart, MS
,
Esmon, CT
,
Peer, GT
,
Taylor, FB
Blood
2001
Participants
Input
PROCR [plasma membrane]
(Homo sapiens)
Protein C [extracellular region]
(Homo sapiens)
Output
PROCR:Protein C [plasma membrane]
(Homo sapiens)
Participates
as an event of
Common Pathway of Fibrin Clot Formation (Homo sapiens)
This event is regulated
Negatively by
Regulator
PROCR(18-?):Activated protein C [extracellular region]
(Homo sapiens)
Orthologous Events
PROCR binds Protein C (Bos taurus)
PROCR binds Protein C (Canis familiaris)
PROCR binds Protein C (Gallus gallus)
PROCR binds Protein C (Mus musculus)
PROCR binds Protein C (Rattus norvegicus)
PROCR binds Protein C (Sus scrofa)
Authored
Jupe, S (2014-07-14)
Reviewed
Mumford, D (2014-09-11)
Created
Jupe, S (2014-06-11)
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