F2R(27-41)

Stable Identifier
R-HSA-114586
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
PAR1 N-terminal fragment
Locations in the PathwayBrowser
Summation

Thrombin recognizes the N-terminal exodomain of PAR1 by interacting with sites both amino and carboxyl terminal to the thrombin cleavage site. Thrombin cleaves the peptide bond between receptor residues Arg41 and Ser42. This serves to unmask a new amino terminus beginning with the sequence SFLLRN that functions as a tethered ligand, docking intramolecularly with the body of the receptor to effect transmembrane signaling. A synthetic peptide of sequence SFLLRN, which mimics the tethered ligand sequence, will function as an agonist for PAR1 independent of receptor cleavage. Thus PAR1 is, in essence, a peptide receptor that carries its own ligand, the latter being active only after receptor cleavage.

External Reference Information
External Reference
Gene Names
F2R, CF2R, PAR1, TR
Chain
signal peptide:1-21, propeptide:22-41, chain:42-425
Other Identifiers
0006660112
11748678_a_at
12962
16986409
1NRN
1NRO
1NRP
1NRQ
1NRR
203989_3p_x_at
203989_x_at
2149
2816460
2816461
2816462
2816465
2816466
2816467
2816468
2816469
2816470
2816471
2816472
2816473
3BEF
3HKI
3HKJ
3LU9
3VW7
41700_at
8106393
8973
A0A024RAP7
A_14_P104930
A_23_P213562
AAA36743
AAH02464
AAH51909
AAK69768
AAP35943
AF391809
BC002464
BC051909
BT007279
CAB008973
CAB012962
CCDS4032
CH471084
EAW95779
EAW95780
ENSG00000181104
ENSP00000321326
ENST00000319211
EntrezGene:2149
F2R
F2R-201
G3XAL6
g6031164_3p_x_at
GE61388
GO:0000186
GO:0001965
GO:0002248
GO:0003013
GO:0003105
GO:0003674
GO:0004871
GO:0004930
GO:0005102
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005623
GO:0005737
GO:0005768
GO:0005769
GO:0005770
GO:0005794
GO:0005886
GO:0005887
GO:0005901
GO:0006464
GO:0006810
GO:0006919
GO:0006950
GO:0006954
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0007205
GO:0007267
GO:0007529
GO:0007596
GO:0007599
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0009058
GO:0009611
GO:0009653
GO:0009986
GO:0014068
GO:0015057
GO:0016020
GO:0016021
GO:0030168
GO:0030193
GO:0030194
GO:0030335
GO:0031094
GO:0031410
GO:0031594
GO:0031681
GO:0032496
GO:0032651
GO:0032967
GO:0034330
GO:0034641
GO:0035025
GO:0040011
GO:0042592
GO:0043123
GO:0043226
GO:0043280
GO:0043410
GO:0043524
GO:0043547
GO:0045211
GO:0045217
GO:0045893
GO:0045907
GO:0045987
GO:0046427
GO:0048856
GO:0048870
GO:0048873
GO:0050877
GO:0051209
GO:0051281
GO:0051482
GO:0051928
GO:0051930
GO:0055085
GO:0060155
GO:0070374
GO:0070493
GO:0099553
GO:1900134
GO:2000484
GO:2000778
HGNC:3537
ILMN_1742866
ILMN_2221507
IPR000276
IPR000935
IPR003912
IPR017452
M62424
M62424_at
MIM:187930
NM_001311313
NM_001992
NP_001298242
NP_001983
PF00001
PH_hs_0007383
PR00237
PR00908
PR01428
TC05000370.hg
uc003ken.5
UPI0000131312
Participant Of
Other forms of this molecule
Inferred To
Cross References
ZINC - World Drugs
ZINC - FDA approved
GeneCards
ZINC - Substances
ZINC target
PRO
ZINC - Predictions - Purchasable
Orphanet
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9UNN8 PROCR  2 0.641 5