F2R(27-425) [plasma membrane]

Stable Identifier
R-HSA-61309
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Proteinase activated receptor 1, PAR-1, Thrombin receptor, Coagulation factor II receptor
Icon
F2R(27-425) [plasma membrane] icon
F2R(27-425) [plasma membrane] icon
Locations in the PathwayBrowser
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General
This is the inactive form of the receptor, before protease activation. Proteinase (protease) activated receptors are activated by the cleavage of an N-terminal extracellular segment by serine proteases, particularly thrombin which activates PAR1, 3 and 4. The cleaved fragment is an activating ligand for the receptor; synthetic peptide mimics of the N-terminal fragment can activate uncleaved receptors.
External Reference Information
External Reference
UniProt:P25116 F2R
Gene Names
F2R, CF2R, PAR1, TR
Chain
signal peptide:1-21, propeptide:22-41, chain:42-425
Reference Genes
BioGPS Gene:2149 F2R
COSMIC (genes):F2R F2R
CTD Gene:2149 F2R
dbSNP Gene:2149 F2R
ENSEMBL:ENSG00000181104 F2R
ENSEMBL_homo_sapiens_GENE:ENSG00000181104.7 F2R
HGNC:3537 F2R
KEGG Gene (Homo sapiens):2149 F2R
Monarch:2149 F2R
NCBI Gene:2149 F2R
OMIM:187930 F2R
UCSC:P25116 F2R
Reference Transcript
Other Identifiers
11748678_a_at
16986409
203989_3p_x_at
203989_PM_x_at
203989_x_at
2149
2816460
2816461
2816462
2816465
2816466
2816467
2816468
2816469
2816470
2816471
2816472
2816473
2816480
2816482
41700_at
8106393
A_14_P104930
A_23_P213562
GE61388
GO:0001965
GO:0002248
GO:0002376
GO:0003012
GO:0003013
GO:0003014
GO:0003105
GO:0004930
GO:0005102
GO:0005515
GO:0005576
GO:0005768
GO:0005769
GO:0005770
GO:0005794
GO:0005886
GO:0005901
GO:0006351
GO:0006355
GO:0006919
GO:0006954
GO:0007165
GO:0007186
GO:0007200
GO:0007204
GO:0007205
GO:0007529
GO:0007596
GO:0007599
GO:0008284
GO:0008285
GO:0009611
GO:0009653
GO:0009986
GO:0012501
GO:0015057
GO:0016020
GO:0023052
GO:0030168
GO:0030193
GO:0030194
GO:0030335
GO:0031094
GO:0031410
GO:0031594
GO:0031681
GO:0032496
GO:0032651
GO:0032755
GO:0032757
GO:0032967
GO:0034330
GO:0035025
GO:0036145
GO:0042060
GO:0043123
GO:0043226
GO:0043280
GO:0043410
GO:0043524
GO:0043547
GO:0045211
GO:0045217
GO:0045893
GO:0045907
GO:0045987
GO:0046427
GO:0048856
GO:0048870
GO:0048873
GO:0050877
GO:0050886
GO:0051209
GO:0051281
GO:0051897
GO:0051928
GO:0051930
GO:0055065
GO:0055085
GO:0060089
GO:0060155
GO:0070374
GO:0070493
GO:0099553
GO:1900134
HMNXSV003012549
ILMN_1742866
ILMN_2221507
M62424_at
PH_hs_0007383
TC05000370.hg
g6031164_3p_x_at
Participates
as a member of
Other forms of this molecule
F2R(27-41) [extracellular region]
pro-F2R [plasma membrane]
Activated F2R [plasma membrane]
Inferred To
F2r [plasma membrane] (Mus musculus)
F2r [plasma membrane] (Rattus norvegicus)
f2r [plasma membrane] (Xenopus tropicalis)
PAR1 [plasma membrane] (Danio rerio)
F2R(27-425) [plasma membrane] (Gallus gallus)
F2R [plasma membrane] (Bos taurus)
F2R [plasma membrane] (Canis familiaris)
F2R [plasma membrane] (Sus scrofa)
gnrr-4 [plasma membrane] (Caenorhabditis elegans)
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
347
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
PRO
PDB
ZINC - Investigational
HPA
GeneCards
Ensembl
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
Interactors (1)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9UNN8 PROCR  2 0.641 5
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