Activated protein C (APC) can either dissociate from PROCR to exert its anticoagulant activity, or remain bound to PROCR where it influences multiple direct cellular activities. Dissociation of APC from PROCR allows APC to associate with other cell membrane surface molecules, various microparticles, or lipoproteins (e.g., high-density lipoprotein). As an anticoagulant, APC cleaves the activated cofactors Va (fVa) and VIIIa (fVIIIa), yielding inactivated cofactors, fVi and fVIIIi. This proteolytic inactivation is enhanced by protein cofactors (e.g., protein S, factor V) and lipids cofactors (e.g., phosphatidylserine, cardiolipin, glucosylceramide, or HDL).