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pro-F2R [plasma membrane]
Stable Identifier
R-HSA-9708861
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PAR1 propeptide, Proteinase activated receptor 1
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Homo sapiens)
pro-F2R [plasma membrane] (Homo sapiens)
pro-F2R binds vorapaxar (Homo sapiens)
pro-F2R [plasma membrane] (Homo sapiens)
pro-F2R:vorapaxar [plasma membrane] (Homo sapiens)
pro-F2R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25116 F2R
Gene Names
F2R, CF2R, PAR1, TR
Chain
signal peptide:1-21, propeptide:22-41, chain:42-425
Reference Genes
BioGPS Gene:2149 F2R
COSMIC (genes):F2R F2R
CTD Gene:2149 F2R
dbSNP Gene:2149 F2R
ENSEMBL:ENSG00000181104 F2R
HGNC:3537 F2R
KEGG:hsa:2149 F2R
Monarch:2149 F2R
NCBI Gene:2149 F2R
OMIM:187930 F2R
UCSC:P25116 F2R
Reference Transcript
RefSeq:NM_001992.4 F2R
RefSeq:NM_001311313.1 F2R
Other Identifiers
11748678_a_at
1569642_PM_at
1569642_at
16986409
203989_3p_x_at
203989_PM_x_at
203989_x_at
2149
2816460
2816461
2816462
2816463
2816465
2816466
2816467
2816468
2816469
2816470
2816471
2816472
2816473
2816480
2816482
41700_at
8106393
A_14_P104930
A_23_P213562
A_33_P3212274
GE61388
GO:0001965
GO:0002248
GO:0002376
GO:0003013
GO:0003014
GO:0003105
GO:0004930
GO:0005102
GO:0005515
GO:0005576
GO:0005768
GO:0005769
GO:0005770
GO:0005794
GO:0005886
GO:0005901
GO:0006355
GO:0006919
GO:0006954
GO:0007186
GO:0007200
GO:0007204
GO:0007529
GO:0007596
GO:0008284
GO:0008285
GO:0009611
GO:0009653
GO:0009986
GO:0015057
GO:0016020
GO:0023052
GO:0030168
GO:0030193
GO:0030194
GO:0030335
GO:0031094
GO:0031410
GO:0031594
GO:0031681
GO:0032496
GO:0032651
GO:0032755
GO:0032757
GO:0032967
GO:0034330
GO:0035025
GO:0036145
GO:0043123
GO:0043226
GO:0043280
GO:0043410
GO:0043524
GO:0043547
GO:0045211
GO:0045217
GO:0045893
GO:0045907
GO:0045987
GO:0046427
GO:0048167
GO:0048873
GO:0051209
GO:0051281
GO:0051897
GO:0051928
GO:0051930
GO:0055085
GO:0060089
GO:0060155
GO:0070374
GO:0070493
GO:0099553
GO:1900134
HMNXSV003012549
HMNXSV003050253
Hs2.378973.1.S1_3p_at
ILMN_1742866
ILMN_2221507
M62424_at
PH_hs_0007383
TC05000370.hg
g6031164_3p_x_at
Participates
as a component of
pro-F2R:vorapaxar [plasma membrane] (Homo sapiens)
as an input of
pro-F2R binds vorapaxar (Homo sapiens)
Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it (Homo sapiens)
Other forms of this molecule
F2R(27-41) [extracellular region]
Activated F2R [plasma membrane]
F2R(27-425) [plasma membrane]
Inferred To
F2r [plasma membrane]
(Mus musculus)
F2r [plasma membrane]
(Rattus norvegicus)
f2r [plasma membrane]
(Danio rerio)
f2r [plasma membrane]
(Xenopus tropicalis)
pro-F2R [plasma membrane]
(Gallus gallus)
F2R [plasma membrane]
(Bos taurus)
F2R [plasma membrane]
(Canis familiaris)
F2R [plasma membrane]
(Sus scrofa)
gnrr-4 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001983.2
,
NP_001298242.1
ZINC - World Drugs
PAR1_HUMAN
Guide to Pharmacology - Targets
347
ENSEMBL
ENSP00000321326
,
ENST00000319211
OpenTargets
ENSG00000181104
ZINC - FDA approved
PAR1_HUMAN
ZINC - Substances
PAR1_HUMAN
ZINC target
P25116
PRO
P25116
GlyGen
P25116
PDB
3VW7
,
3HKI
,
3HKJ
,
1NRR
,
1NRQ
,
3LU9
,
1NRP
,
1NRO
,
1NRN
,
3BEF
ZINC - Investigational
PAR1_HUMAN
HPA
ENSG00000181104-F2R
Pharos - Targets
P25116
ZINC - Predictions - Purchasable
PAR1_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UNN8 PROCR
2
PROCR(18-?) [extracellular region]
(R-HSA-5610109)
PROCR [plasma membrane]
(R-HSA-5591027)
0.641
5
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