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55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
Stable Identifier
R-HSA-9937716
Type
Complex
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial ribosome-associated quality control (Homo sapiens)
55S mitochondrial ribosome:non-stop mRNA binds ICT1 (MRPL58) (Homo sapiens)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane] (Homo sapiens)
ICT1 hydrolyzes the peptidyl-tRNA bond of the nascent polypeptide (Homo sapiens)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
33878294
Structural basis of translation termination, rescue, and recycling in mammalian mitochondria
Kummer, E
,
Schubert, KN
,
Schoenhut, T
,
Scaiola, A
,
Ban, N
Mol Cell
2021
Participants
components
55S ribosome [mitochondrial inner membrane]
(Homo sapiens)
ICT1 [mitochondrial matrix]
(Homo sapiens)
Mature tRNA with 3' CCA [mitochondrial matrix]
(Homo sapiens)
non-stop mRNA [mitochondrial matrix]
(Homo sapiens)
peptidyl-tRNA with elongated peptide [mitochondrial inner membrane]
Participates
as an input of
ICT1 hydrolyzes the peptidyl-tRNA bond of the nascent polypeptide (Homo sapiens)
as an output of
55S mitochondrial ribosome:non-stop mRNA binds ICT1 (MRPL58) (Homo sapiens)
Inferred To
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Bos taurus)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Caenorhabditis elegans)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Canis familiaris)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Danio rerio)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Drosophila melanogaster)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Gallus gallus)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Mus musculus)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Rattus norvegicus)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Sus scrofa)
55S ribosome:non-stop mRNA:peptidyl-tRNA at P-site:tRNA at E-site:ICT1 [mitochondrial inner membrane]
(Xenopus tropicalis)
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