Reactome | MTRF1L, ICT1 [mitochondrial matrix]

MTRF1L, ICT1 [mitochondrial matrix]

Stable Identifier

R-HSA-5432633

Type

Set [DefinedSet]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

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General

Both MTRF1L and ICT1 can bind a standard stop codon in the A-site of the ribosome and cause release of the polypeptide. ICT1 can also cause release of ribosomes stalled in non-standard conformations (e.g. non-standard stop codons, mRNA lacking a stop codon) (inferred from pig mitoribosomes in Akabane et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
20421313	Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria Young, DJ, Edgar, CD, Murphy, J, Fredebohm, J, Poole, ES, Tate, WP	RNA	2010
24352605	Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons Lind, C, Sund, J, Aqvist, J	Nat Commun	2013
25233460	Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria Akabane, S, Ueda, T, Nierhaus, KH, Takeuchi, N	PLoS Genet.	2014