Reactome | MTRF1L, ICT1 [mitochondrial matrix]

MTRF1L, ICT1 [mitochondrial matrix]

Stable Identifier

R-HSA-5432633

Type

Set [DefinedSet]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

Expand all

General

Both MTRF1L and ICT1 can bind a standard stop codon in the A-site of the ribosome and cause release of the polypeptide. ICT1 can also cause release of ribosomes stalled in non-standard conformations (e.g. non-standard stop codons, mRNA lacking a stop codon) (inferred from pig mitoribosomes in Akabane et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
24352605	Codon-reading specificities of mitochondrial release factors and translation termination at non-standard stop codons Lind, C, Sund, J, Aqvist, J	Nat Commun	2013
20421313	Bioinformatic, structural, and functional analyses support release factor-like MTRF1 as a protein able to decode nonstandard stop codons beginning with adenine in vertebrate mitochondria Young, DJ, Edgar, CD, Murphy, J, Fredebohm, J, Poole, ES, Tate, WP	RNA	2010
25233460	Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria Akabane, S, Ueda, T, Nierhaus, KH, Takeuchi, N	PLoS Genet.	2014