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MRPL4 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5368212
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
39S ribosomal protein L4, mitochondrial, RM04_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Mitochondrial translation (Homo sapiens)
Mitochondrial translation elongation (Homo sapiens)
55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
Peptide transfer from P-site to A-site (peptide bond formation) (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA at A-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA:aminoacyl-tRNA:TUFM:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:peptidyl-tRNA:GFM1:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation initiation (Homo sapiens)
39S subunit binds 28S subunit:mRNA:fMet-tRNA (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:fMet-tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
Mitochondrial translation termination (Homo sapiens)
55S ribosome hydrolyzes peptidyl-tRNA bond and MTRF1L hydrolyzes GTP (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
Hydrolysis of GTP and dissociation of 28S and 39S subunits (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:MRRF:GFM2:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
MRRF binds 55S ribosome:mRNA:tRNA (Homo sapiens)
55S ribosome:mRNA:tRNA [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:tRNA:MRRF [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA at P-site [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
55S ribosome:mRNA:peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane] (Homo sapiens)
55S ribosome [mitochondrial inner membrane] (Homo sapiens)
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
MRPL4 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BYD3 MRPL4
Gene Names
MRPL4, CDABP0091, CGI-28
Chain
chain:1-311
Reference Genes
BioGPS Gene:51073 MRPL4
COSMIC (genes):MRPL4 MRPL4
CTD Gene:51073 MRPL4
dbSNP Gene:51073 MRPL4
ENSEMBL:ENSG00000105364 MRPL4
HGNC:14276 MRPL4
KEGG:hsa:51073 MRPL4
Monarch:51073 MRPL4
NCBI Gene:51073 MRPL4
OMIM:611823 MRPL4
UCSC:Q9BYD3 MRPL4
Reference Transcript
RefSeq:NM_146388.1 MRPL4
RefSeq:NM_015956.2 MRPL4
RefSeq:NM_146387.1 MRPL4
Other Identifiers
11718011_a_at
11730793_a_at
11730794_x_at
11730795_at
16858122
218105_PM_s_at
218105_s_at
223742_PM_at
223742_at
223743_PM_s_at
223743_s_at
3820415
3820416
3820417
3820418
3820419
3820420
3820421
3820422
3820423
3820424
3820425
3820426
3820427
3820428
3820429
3820430
3820431
3820432
3820433
3820434
3820435
3820436
3820437
3820438
3820439
3820440
45335_at
51073
8025586
A_14_P126232
A_23_P164702
A_33_P3390477
GE528775
GE82055
GO:0003723
GO:0003735
GO:0005198
GO:0005515
GO:0005739
GO:0005743
GO:0005762
GO:0005840
GO:0006412
GO:0032543
GO:0043226
GO:1990904
HMNXSV003040705
ILMN_1681230
ILMN_1804207
ILMN_2352042
PH_hs_0014378
TC19000173.hg
TC19001976.hg
g12653924_3p_at
g7705721_3p_s_at
Participates
as a component of
39S ribosomal subunit [mitochondrial inner membrane] (Homo sapiens)
Inferred To
mrpl-4 [mitochondrial inner membrane]
(Caenorhabditis elegans)
Mrpl4 [mitochondrial inner membrane]
(Mus musculus)
Mrpl4 [mitochondrial inner membrane]
(Rattus norvegicus)
MRPL4 [mitochondrial inner membrane]
(Bos taurus)
MRPL4 [mitochondrial inner membrane]
(Canis familiaris)
MRPL4 [mitochondrial inner membrane]
(Gallus gallus)
MRPL4 [mitochondrial inner membrane]
(Sus scrofa)
mRpL4 [mitochondrial inner membrane]
(Drosophila melanogaster)
mrpl4 [mitochondrial inner membrane]
(Danio rerio)
Cross References
OpenTargets
ENSG00000105364
ENSEMBL
ENST00000253099
,
ENST00000590669
,
ENSP00000306902
,
ENSP00000253099
,
ENSP00000465143
,
ENST00000307422
HPA
ENSG00000105364-MRPL4
PRO
Q9BYD3
Pharos - Targets
Q9BYD3
GlyGen
Q9BYD3
PDB
6ZS9
,
8OIR
,
7O9M
,
7OF5
,
7OF3
,
6ZSD
,
7OI9
,
6ZSE
,
7OIA
,
7OIC
,
7OI7
,
7L08
,
7ODS
,
7QI6
,
7QI4
,
5OOM
,
6NU3
,
7A5K
,
3J7Y
,
7OF6
,
8PK0
,
8QSJ
,
3IY9
,
6VMI
,
3J9M
,
6I9R
,
7A5H
,
5OOL
,
8ANY
,
7A5J
,
6ZM6
,
6VLZ
,
7OF7
,
6ZSB
,
6ZSA
,
8OIT
,
7OF4
,
7OF2
,
6ZSG
,
6ZSC
,
7ODT
,
7ODR
,
7QI5
,
7OIB
,
7OID
,
7A5F
,
7OI8
,
7OI6
,
6NU2
,
7OF0
,
7O9K
,
7PD3
,
7PO4
,
7OG4
,
7QH6
,
7OIE
,
7A5G
,
7QH7
,
7A5I
,
6ZM5
,
7L20
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
3
UniProt:P10809 HSPD1
6
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
0.483
3
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