Reactome | CCNT1 [nucleoplasm]

CCNT1 [nucleoplasm]

Stable Identifier

R-BTA-51611

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

nucleoplasm

Synonyms

CCNT1, Q6T8E9

Locations in the PathwayBrowser

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Gene expression (Transcription) (Bos taurus)

- RNA Polymerase II Transcription (Bos taurus)
  - Generic Transcription Pathway (Bos taurus)
    - Transcriptional Regulation by TP53 (Bos taurus)
      - TP53 Regulates Transcription of DNA Repair Genes (Bos taurus)
        
        CCNK:CDK12 binds RNA Pol II at DNA repair genes (Bos taurus)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
        
        CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Bos taurus)
        
        CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Bos taurus)
        
        CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Bos taurus)
        
        CDK12-phosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
        
        CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Elongation Complex at DNA Repair Genes [nucleoplasm] (Bos taurus)
        
        Hyperphosphorylated RNA Pol II at DNA repair genes [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
  - RNA Polymerase II Pre-transcription Events (Bos taurus)
    - 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing (Bos taurus)
      - Paused processive elongation complex [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Abortive termination of elongation after arrest (Bos taurus)
      - Aborted elongation complex after arrest [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Formation of P-TEFb complex (Bos taurus)
      - CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Resumption of elongation after recovery from pausing (Bos taurus)
      - Paused processive elongation complex [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - TFIIS-mediated recovery of elongation from arrest (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
  - RNA Polymerase II Transcription Elongation (Bos taurus)
    - Addition of nucleotides leads to transcript elongation (Bos taurus)
      - Elongation complex [nucleoplasm] (Bos taurus)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Formation of RNA Pol II elongation complex (Bos taurus)
      - Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex (Bos taurus)
        
        Early elongation complex with hyperphosphorylated Pol II CTD [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Pol II elongation complex moves on the template as transcript elongates (Bos taurus)
      - Elongation complex prior to separation [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - Processive elongation complex [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Separation of elongating transcript from template (Bos taurus)
      - Elongation complex prior to separation [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - Elongation complex with separated and uncleaved transcript [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
  - RNA polymerase II transcribes snRNA genes (Bos taurus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Bos taurus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Integrator complex processes the 3' end of snRNA (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Bos taurus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Bos taurus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Bos taurus)
        
        RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Bos taurus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Bos taurus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by Nuclear Receptors (Bos taurus)
  - ESR-mediated signaling (Bos taurus)
    - Estrogen-dependent gene expression (Bos taurus)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Bos taurus)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Bos taurus)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Bos taurus)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)
- Signaling by TGFB family members (Bos taurus)
  - Signaling by TGF-beta Receptor Complex (Bos taurus)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Bos taurus)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Bos taurus)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Bos taurus)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Bos taurus)
        
        P-TEFb complex [nucleoplasm] (Bos taurus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)
        
        CCNT1 [nucleoplasm] (Bos taurus)

External Reference Information

External Reference

UniProt:Q6T8E9

Gene Names

CCNT1

Reference Genes

BioGPS Gene:407194 CCNT1

ENSEMBL:ENSBTAG00000005861

ENSEMBL:ENSBTAG00000005861.5 CCNT1

KEGG Gene (Bos taurus):407194 CCNT1

Monarch:407194 CCNT1

NCBI Gene:407194 CCNT1

Reference Transcript

RefSeq:NM_001001147.1 CCNT1

Other Identifiers

407194

GO:0000976

GO:0003677

GO:0003682

GO:0003723

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0007049

GO:0008024

GO:0016538

GO:0017069

GO:0019901

GO:0032786

GO:0032968

GO:0043226

GO:0043923

GO:0045944

GO:0051301

GO:0060090

GO:0061575

GO:0070063

GO:0070691

GO:0097322

GO:0098772

GO:0140297

GO:0140693

Participates

as a component of

P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Bos taurus)

as a member of

CCNT1,CCNT2,CCNK [nucleoplasm] (Bos taurus)

Inferred From

CCNT1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001001147.1

OpenTargets

ENSG00000129315

Ensembl

ENSBTAT00000007703, ENSBTAG00000005861, ENSBTAP00000007703

VGNC

26978

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