Reactome | Ccnt1 [nucleoplasm]

Ccnt1 [nucleoplasm]

Stable Identifier

R-MMU-51611

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

CCNT1, Q9QWV9

Locations in the PathwayBrowser

Expand all

Signal Transduction (Mus musculus)

- Signaling by Nuclear Receptors (Mus musculus)
  - ESR-mediated signaling (Mus musculus)
    - Estrogen-dependent gene expression (Mus musculus)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Mus musculus)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Mus musculus)
        
        Ccnt1 [nucleoplasm] (Mus musculus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Mus musculus)
        
        Ccnt1 [nucleoplasm] (Mus musculus)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Mus musculus)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Mus musculus)
        
        Ccnt1 [nucleoplasm] (Mus musculus)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Mus musculus)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Mus musculus)
        
        Ccnt1 [nucleoplasm] (Mus musculus)
- Signaling by TGFB family members (Mus musculus)
  - Signaling by TGF-beta Receptor Complex (Mus musculus)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Mus musculus)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Mus musculus)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Mus musculus)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Mus musculus)
        
        P-TEFb complex [nucleoplasm] (Mus musculus)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Mus musculus)
        
        Ccnt1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QWV9

Gene Names

Ccnt1

Reference Genes

BioGPS Gene:12455 Ccnt1

ENSEMBL:ENSMUSG00000011960

KEGG:mmu:12455 Ccnt1

Monarch:12455 Ccnt1

NCBI Gene:12455 Ccnt1

UCSC:Q9QWV9 Ccnt1

Reference Transcript

RefSeq:NM_009833.2 Ccnt1

Other Identifiers

10432180

110276_at

12455

1419313_at

1456477_at

17321248

4337389

4436803

4463532

4490189

4500967

4642624

4648154

4686039

4759843

4860948

4864630

4971188

5004460

5061242

5095047

5115016

5119867

5170560

5243678

5279488

5329180

5352244

5390534

5391263

5461665

5504860

5611793

93712_at

A_51_P356425

A_52_P406134

A_55_P1962274

A_55_P2040921

A_55_P2107117

A_55_P2721073

A_55_P2928148

A_65_P02482

GE1557825

GE35169

GO:0000976

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006355

GO:0006357

GO:0008024

GO:0009410

GO:0016538

GO:0017069

GO:0019901

GO:0032786

GO:0032968

GO:0043923

GO:0045944

GO:0051301

GO:0060090

GO:0061575

GO:0070063

GO:0070691

GO:0097322

GO:0098772

GO:0140297

GO:0140693

ILMN_1239224

ILMN_2758087

mMC010043

mMC022790

Participates

as a component of

P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Mus musculus)

as a member of

CCNT1,CCNT2,CCNK [nucleoplasm] (Mus musculus)

Inferred From

CCNT1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_033963.1

ENSEMBL

ENSMUSP00000012104, ENSMUSG00000011960, ENSMUST00000169707, ENSMUST00000012104, ENSMUSP00000126874

PRO

Q9QWV9

MGI

1328363

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99J95	1	CDK9 [nucleoplasm] (R-MMU-51801)	0.527	4

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