Reactome | Degradation of AXIN

Degradation of AXIN

Stable Identifier

R-HSA-4641257

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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AXIN is present in low concentrations in the cell and is considered to be the limiting component of the beta-catenin destruction complex in Xenopus; this may not be the case in mammalian cells, however (Lee et al, 2003; Tan et al, 2012). Cellular levels of AXIN are regulated in part through ubiquitin-mediated turnover. E3 ligases SMURF2 and RNF146 have both been shown to play a role in promoting the degradation of AXIN by the 26S proteasome (Kim and Jho, 2010; Callow et al, 2011; Zhang et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
21478859	RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling Zhang, Y, Liu, S, Mickanin, C, Feng, Y, Charlat, O, Michaud, GA, Schirle, M, Shi, X, Hild, M, Bauer, A, Myer, VE, Finan, PM, Porter, JA, Huang, SM, Cong, F	Nat. Cell Biol.	2011
20858899	The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2) Kim, S, Jho, EH	J. Biol. Chem.	2010
14551908	The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway Lee, E, Salic, A, Kruger, R, Heinrich, R, Kirschner, MW	PLoS Biol	2003
21799911	Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling Callow, MG, Tran, H, Phu, L, Lau, T, Lee, J, Sandoval, WN, Liu, PS, Bheddah, S, Tao, J, Lill, JR, Hongo, JA, Davis, D, Kirkpatrick, DS, Polakis, P, Costa, M	PLoS ONE	2011
22363759	Wnt signalling pathway parameters for mammalian cells Tan, CW, Gardiner, BS, Hirokawa, Y, Layton, MJ, Smith, DW, Burgess, AW	PLoS ONE	2012