Reactome | RNF146 ubiquitinates ADP-ribosylated AXIN

RNF146 ubiquitinates ADP-ribosylated AXIN

Stable Identifier

R-HSA-3640861

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RNF146 ubiquitinates ADP-ribosylated AXIN

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RNF146 has in vitro and in vivo ubiquitination activity against AXIN, Tankyrase and itself (Callow et al, 2011; Zhang et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
21478859	RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling Mickanin, C, Zhang, Y, Shi, X, Charlat, O, Feng, Y, Cong, F, Schirle, M, Michaud, GA, Hild, M, Porter, JA, Bauer, A, Huang, SM, Myer, VE, Finan, PM, Liu, S	Nat. Cell Biol.	2011
21799911	Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling Kirkpatrick, DS, Bheddah, S, Lau, T, Callow, MG, Lee, J, Davis, D, Sandoval, WN, Polakis, P, Tran, H, Lill, JR, Hongo, JA, Costa, M, Liu, PS, Tao, J, Phu, L	PLoS ONE	2011