SMURF2 binds AXIN

Stable Identifier
R-HSA-4641134
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMURF2 binds AXIN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SMURF2 is an E3 ubiquitin ligase for AXIN and promotes its ubiquitin-mediated degradation. Ectopic SMURF2 immunoprecipitates both exogenously expressed and endogenous AXIN. AXIN is polyubiquitinated by SMURF2 at lysine 505 both in vitro and in vivo (Kim and Jho, 2012).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
SMURF2 binds AXIN (Danio rerio)
SMURF2 binds AXIN (Drosophila melanogaster)
SMURF2 binds AXIN (Gallus gallus)
SMURF2 binds AXIN (Mus musculus)
SMURF2 binds AXIN (Rattus norvegicus)
SMURF2 binds AXIN (Sus scrofa)
SMURF2 binds AXIN (Xenopus tropicalis)
Authored
Rothfels, K  (2013-09-23)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-09-28)
Cite Us!