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AXIN is ubiquitinated by SMURF2
Stable Identifier
R-HSA-4641129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
AXIN is ubiquitinated by SMURF2 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SMURF2 has been shown to ubiquitinate AXIN at lysine 505 both in vitro and in vivo in a manner that depends on the interaction between the two proteins (Kim and Jho, 2012).
Literature References
PubMed ID
Title
Journal
Year
20858899
The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2)
Jho, EH
,
Kim, S
J. Biol. Chem.
2010
Participants
Input
AXIN:SMURF2 [cytosol]
(Homo sapiens)
Ub [cytosol]
(Homo sapiens)
Output
ub-AXIN:SMURF2 [cytosol]
(Homo sapiens)
Participates
as an event of
Degradation of AXIN (Homo sapiens)
Catalyst Activity
ubiquitin protein ligase activity of AXIN:SMURF2 [cytosol]
Physical Entity
AXIN:SMURF2 [cytosol]
(Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
AXIN is ubiquitinated by SMURF2 (Bos taurus)
AXIN is ubiquitinated by SMURF2 (Canis familiaris)
AXIN is ubiquitinated by SMURF2 (Danio rerio)
AXIN is ubiquitinated by SMURF2 (Drosophila melanogaster)
AXIN is ubiquitinated by SMURF2 (Gallus gallus)
AXIN is ubiquitinated by SMURF2 (Mus musculus)
AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)
AXIN is ubiquitinated by SMURF2 (Sus scrofa)
AXIN is ubiquitinated by SMURF2 (Xenopus tropicalis)
Authored
Rothfels, K (2013-09-23)
Reviewed
Rajakulendran, N (2014-01-22)
van Amerongen, R (2014-02-15)
Kikuchi, A (2014-04-22)
Created
Rothfels, K (2013-09-28)
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