AXIN is ubiquitinated by SMURF2

Stable Identifier
R-HSA-4641129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AXIN is ubiquitinated by SMURF2
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SMURF2 has been shown to ubiquitinate AXIN at lysine 505 both in vitro and in vivo in a manner that depends on the interaction between the two proteins (Kim and Jho, 2012).

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Catalyst Activity

ubiquitin protein ligase activity of AXIN:SMURF2 [cytosol]

Physical Entity
AXIN:SMURF2 [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
AXIN is ubiquitinated by SMURF2 (Bos taurus)
AXIN is ubiquitinated by SMURF2 (Canis familiaris)
AXIN is ubiquitinated by SMURF2 (Danio rerio)
AXIN is ubiquitinated by SMURF2 (Drosophila melanogaster)
AXIN is ubiquitinated by SMURF2 (Gallus gallus)
AXIN is ubiquitinated by SMURF2 (Mus musculus)
AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)
AXIN is ubiquitinated by SMURF2 (Sus scrofa)
AXIN is ubiquitinated by SMURF2 (Xenopus tropicalis)
Authored
Rothfels, K  (2013-09-23)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-09-28)
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