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EOMES [nucleoplasm]
Stable Identifier
R-HSA-452232
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Eomesodermin homolog, EOMES_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Cardiogenesis (Homo sapiens)
EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES:WDR5:KAT2A:TBXT:MESP1 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Expression of MESP1 in cardiogenesis (Homo sapiens)
EOMES:WDR5:KAT2A:TBXT:MESP1 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Gastrulation (Homo sapiens)
Epithelial-Mesenchymal Transition (EMT) during gastrulation (Homo sapiens)
EOMES and TBXT (T, Brachyury) bind the SNAI1 gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES:TBXT:SNAI1 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Expression of SNAI1 during gastrulation (Homo sapiens)
EOMES:TBXT:SNAI1 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Formation of definitive endoderm (Homo sapiens)
EOMES, SMAD2,3, MIXL1 bind the GSC gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES:p-2S-SMAD2,3:SMAD4:GATA6:CXCR4 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Expression of CXCR4 in definitive endoderm (Homo sapiens)
EOMES:p-2S-SMAD2,3:SMAD4:GATA6:CXCR4 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Expression of FOXA2 in definitive endoderm (Homo sapiens)
EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Expression of GSC in definitive endoderm (Homo sapiens)
EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Expression of SOX17 in definitive endoderm (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Germ layer formation at gastrulation (Homo sapiens)
EOMES and TBXT bind the NANOG gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES:TBXT:NANOG gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES and TBXT bind the POU5F1 (OCT4) gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES:TBXT:POU5F1 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES and TBXT bind the SOX2 gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
EOMES:TBXT:SOX2 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Expression of EOMES in the primitive streak (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Expression of Goosecoid (GSC) in the primitive streak (Homo sapiens)
p-2S-SMAD2,3:SMAD4:TRIM33:CTNNB1:FOXH1:SMAD3:EOMES:TBPL2:GSC gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Expression of MIXL1 in the primitive streak (Homo sapiens)
p-2S-SMAD2,3:TRIM33:p-2S-SMAD2,3:SMAD4:CTNNB1:FOXH1:EOMES:TBPL2:MIXL1 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4, p-2S-SMAD2,3:TRIM33, CTNNB1, EOMES, and TBPL2 bind FOXH1:SMAD3:GSC gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:TRIM33:CTNNB1:FOXH1:SMAD3:EOMES:TBPL2:GSC gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:TRIM33:p-2S-SMAD2,3:SMAD4:CTNNB1:FOXH1:EOMES:TBPL2:MIXL1 gene [nucleoplasm] (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Specification of primordial germ cells (Homo sapiens)
Expression of SOX17 in primordial germ cells (Homo sapiens)
EOMES [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95936 EOMES
Gene Names
EOMES, TBR2
Chain
chain:1-686
Reference Genes
BioGPS Gene:8320 EOMES
COSMIC (genes):EOMES EOMES
CTD Gene:8320 EOMES
dbSNP Gene:8320 EOMES
ENSEMBL:ENSG00000163508 EOMES
ENSEMBL_homo_sapiens_GENE:ENSG00000163508.13 EOMES
HGNC:3372 EOMES
KEGG Gene (Homo sapiens):8320 EOMES
Monarch:8320 EOMES
NCBI Gene:8320 EOMES
OMIM:604615 EOMES
UCSC:O95936 EOMES
Reference Transcript
RefSeq:NM_001278183.1 EOMES
RefSeq:NM_005442.3 EOMES
RefSeq:NM_001278182.1 EOMES
Other Identifiers
11737237_a_at
11737238_s_at
11737239_x_at
11750304_a_at
11750731_a_at
11750811_x_at
16951797
231776_PM_at
231776_at
2667041
2667042
2667043
2667044
2667045
2667046
2667047
2667048
2667049
2667050
2667051
2667053
2667056
2667057
2667062
2667063
2667064
2667065
2667066
2667067
2667068
2667069
2667070
2667071
2667072
2667073
2667074
2667075
2667081
2667083
2667085
55918_at
8085946
8320
A_24_P97374
GE81510
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001706
GO:0001707
GO:0001714
GO:0001764
GO:0001824
GO:0001829
GO:0002250
GO:0002302
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006306
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0007369
GO:0007420
GO:0007492
GO:0009653
GO:0010002
GO:0010467
GO:0010468
GO:0019827
GO:0021772
GO:0021796
GO:0021895
GO:0021987
GO:0022008
GO:0022414
GO:0030154
GO:0030182
GO:0031490
GO:0035914
GO:0043226
GO:0043433
GO:0043565
GO:0045893
GO:0045944
GO:0048382
GO:0048708
GO:0048856
GO:0048870
GO:0060706
GO:0060809
GO:0061629
GO:0080111
GO:0140110
GO:1990837
HMNXSV003030573
Hs.301704.0.S2_3p_at
ILMN_1760509
PH_hs_0022626
TC03001257.hg
Participates
as a component of
EOMES:WDR5:KAT2A:TBXT:MESP1 gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:NANOG gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:POU5F1 gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:SOX2 gene [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:SMAD4:TRIM33:CTNNB1:FOXH1:SMAD3:EOMES:TBPL2:GSC gene [nucleoplasm] (Homo sapiens)
EOMES:p-2S-SMAD2,3:SMAD4:MIXL1:GSC gene [nucleoplasm] (Homo sapiens)
EOMES:p-2S-SMAD2,3:SMAD4:GATA6:CXCR4 gene [nucleoplasm] (Homo sapiens)
p-2S-SMAD2,3:TRIM33:p-2S-SMAD2,3:SMAD4:CTNNB1:FOXH1:EOMES:TBPL2:MIXL1 gene [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:GATA6:p-2S-SMAD2,3:SMAD4:FOXA2 gene [nucleoplasm] (Homo sapiens)
EOMES:TBXT:SNAI1 gene [nucleoplasm] (Homo sapiens)
as an input of
EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene (Homo sapiens)
EOMES and TBXT bind the NANOG gene (Homo sapiens)
EOMES and TBXT bind the POU5F1 (OCT4) gene (Homo sapiens)
EOMES and TBXT bind the SOX2 gene (Homo sapiens)
p-2S-SMAD2,3:SMAD4, p-2S-SMAD2,3:TRIM33, CTNNB1, EOMES, and TBPL2 bind FOXH1:SMAD3:GSC gene (Homo sapiens)
EOMES, SMAD2,3, MIXL1 bind the GSC gene (Homo sapiens)
EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene (Homo sapiens)
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
p-2S-SMAD2,3:TRIM33, p-2S-SMAD2,3:SMAD4, CTNNB1, EOMES, and TBPL2 bind FOXH1:MIXL1 gene (Homo sapiens)
EOMES, TBXT (T BRACHYURY), GATA6, and SMAD2,3 bind the FOXA2 gene (Homo sapiens)
EOMES and TBXT (T, Brachyury) bind the SNAI1 gene (Homo sapiens)
as an output of
Expression of EOMES in the primitive streak (Homo sapiens)
This entity regulates
Positively
Expression of SOX17 in primordial germ cells
(Homo sapiens)
Inferred To
org-1 [nucleoplasm]
(Drosophila melanogaster)
eomes [nucleoplasm]
(Xenopus tropicalis)
EOMES [nucleoplasm]
(Bos taurus)
EOMES [nucleoplasm]
(Canis familiaris)
EOMES [nucleoplasm]
(Gallus gallus)
EOMES [nucleoplasm]
(Sus scrofa)
tbx-35 [nucleoplasm]
(Caenorhabditis elegans)
Eomes [nucleoplasm]
(Mus musculus)
Eomes [nucleoplasm]
(Rattus norvegicus)
Homologues of EOMES [nucleoplasm]
(Caenorhabditis elegans)
eomesa [nucleoplasm]
(Danio rerio)
tbx-7 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001265111.1
,
NP_001265112.1
,
NP_005433.2
OpenTargets
ENSG00000163508
HPA
ENSG00000163508-EOMES
GeneCards
O95936
Ensembl
ENSG00000163508
,
ENSP00000295743
,
ENSP00000388620
,
ENST00000449599
,
ENST00000295743
,
ENSP00000487112
,
ENST00000461503
PRO
O95936
Pharos - Targets
O95936
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