Expression of SOX17 in primordial germ cells

Stable Identifier
R-HSA-9828100
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of SOX17 in primordial germ cells
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WNT signaling activates expression of Eomesodermin (EOMES), which in turn activates expression of SOX17 in precursors of primordial germ cells (PGCs), possibly by binding the SOX17 gene (Chen et al. 2017, Kojima et al. 2017). BMP4 signaling, required for specification of PGCs, enhances expression of SOX17 in precursors of PGCs (Kojima et al. 2017). SOX17 is a critical factor for the differentiation of both PGCs and endoderm and it appears to act combinatorially with other factors to generate either PGCs or endoderm. PRDM1 represses genes expressed in endoderm and hence facilitates the formation of PGCs (Irie et al. 2015).
Literature References
PubMed ID Title Journal Year
29091993 Germline competency of human embryonic stem cells depends on eomesodermin

Chen, D, Liu, W, Lukianchikov, A, Hancock, GV, Zimmerman, J, Lowe, MG, Kim, R, Galic, Z, Irie, N, Surani, MA, Jacobsen, SE, Clark, AT

Biol Reprod 2017
26189426 Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells

Sasaki, K, Yokobayashi, S, Nakamura, T, Okamoto, I, Yabuta, Y, Kurimoto, K, Ohta, H, Moritoki, Y, Iwatani, C, Tsuchiya, H, Nakamura, S, Sekiguchi, K, Sakuma, T, Yamamoto, T, Mori, T, Woltjen, K, Nakagawa, M, Yamamoto, T, Takahashi, K, Yamanaka, S, Saitou, M

Cell Stem Cell 2015
28985527 Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells

Kojima, Y, Sasaki, K, Yokobayashi, S, Sakai, Y, Nakamura, T, Yabuta, Y, Nakaki, F, Nagaoka, S, Woltjen, K, Hotta, A, Yamamoto, T, Saitou, M

Cell Stem Cell 2017
25543152 SOX17 is a critical specifier of human primordial germ cell fate

Irie, N, Weinberger, L, Tang, WW, Kobayashi, T, Viukov, S, Manor, YS, Dietmann, S, Hanna, JH, Surani, MA

Cell 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
BMP4 dimer [extracellular region] (Homo sapiens)
Regulator
EOMES [nucleoplasm] (Homo sapiens)
Authored
May, B  (2023-02-09)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2023-02-10)
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