EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene

Stable Identifier
R-HSA-9733781
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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EOMES, WDR5, KAT2A, and TBXT bind the MESP1 gene
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Mesodermal proteins EOMES and TBXT (T, Brachyury) bind the promoter of the MESP1 gene and activate transcription of MESP1 (inferred from mouse homologs). EOMES forms a complex with the histone acetyltransferase KAT2A and the histone-binding protein WDR5 (inferred from mouse homologs). (WDR5 is a component of trithorax group/MLL histone acetyltransferase complexes therefore a MLL complex may bind the MESP1 gene but this has not yet been demonstrated.) MESP1 is the first observed marker of cardiac progenitor cells within the lateral plate mesoderm.
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Eomes, Wdr5, Kat2a, Tbxt bind the Mesp1 gene (Mus musculus)
Authored
May, B  (2021-06-07)
Created
May, B  (2021-06-10)
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