EOMES, SMAD2,3, MIXL1 bind the GSC gene

Stable Identifier
R-HSA-9823966
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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EOMES, SMAD2,3, MIXL1 bind the GSC gene
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NODAL signaling causes the phosphorylation of SMAD2 and SMAD3 which transit with SMAD4 into the nucleus and, in concert with EOMES (Teo et al. 2011), bind an upstream enhancer of the GOOSECOID (GSC) gene (inferred from human pluripotent stem cells in Brown et al. 2011, Teo et al. 2011, Daneshvar et al. 2016). SMAD2,3 also activates transcription of DIGIT, a long noncoding RNA located between the enhancer and the GSC coding region that enhances transcription of GSC (Daneshvar et al. 2016). MIXL1 binds elements in the promoter of the GSC gene (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Dunn, NR, Lim, B, Cho, CH, Vallier, L, Pedersen, R, Hannan, N, Teo, A, Vardy, L, Brown, S, Trotter, M, Pauklin, S

Stem Cells 2011
21245162 Pluripotency factors regulate definitive endoderm specification through eomesodermin

Dunn, NR, Chng, Z, Trotter, MW, Vallier, L, Teo, AK, Ang, LT, Brown, S, Arnold, SJ, Robertson, EJ

Genes Dev. 2011
27705785 DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells

York, SR, Macklin, JA, Tan, B, Abualteen, A, Sigova, AA, Kim, BM, Daneshvar, K, Mullen, AC, Tremblay, KD, Zhou, C, Pondick, JV, Choi, MY, Mager, J, Marcho, C

Cell Rep 2016
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Input
Output
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as an event of
Inferred From
Mixl1 binds the Gsc gene (Mus musculus)
Authored
May, B  (2023-01-11)
Reviewed
Tam, PPL  (2023-02-28)
Salehin, N  (2023-02-28)
Created
May, B  (2023-01-13)
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