EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene

Stable Identifier
R-HSA-9823952
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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EOMES, SMAD2,3, and GATA6 bind the CXCR4 gene
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NODAL signaling in the primitive streak leads to the phosphorylation of SMAD2 and SMAD3, which transit with SMAD4 to the nucleus and bind the promoter of the CXCR4 gene (inferred from human pluripotent stem cells in Brown et al. 2011). EOMES and GATA6, also expressed in the primitive streak, bind the CXCR4 promoter together with the SMADs and activate expression (inferred from human pluripotent stem cells in Chia et al. 2019).
Literature References
PubMed ID Title Journal Year
30629940 GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation

Dunn, NR, Garcia-Bernardo, J, Chia, CY, Hattersley, AT, Madrigal, P, Vallier, L, Chhatriwala, M, Denil, SLIJ, El-Khairi, R, Shepherd, MH, Martinez, I

Stem Cell Reports 2019
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Dunn, NR, Lim, B, Cho, CH, Vallier, L, Pedersen, R, Hannan, N, Teo, A, Vardy, L, Brown, S, Trotter, M, Pauklin, S

Stem Cells 2011
Participants
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Output
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Authored
May, B  (2023-01-11)
Reviewed
Tam, PPL  (2023-02-28)
Salehin, N  (2023-02-28)
Created
May, B  (2023-01-13)
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