TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene

Stable Identifier
R-HSA-9824472
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene
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In mice, the Sox17 transcription factor is expressed in prospective definitive endoderm cells before intercalation of the definitive endoderm cells with the visceral endoderm (Viotti et al. 2014). Sox17 is necessary for gut endoderm formation in mice (Viotti et al. 2014). TCF7L2:CTNNB1 from WNT signaling (inferred from mouse homologs) and phosphorylated SMAD2 and SMAD3 from NODAL signaling (inferred from human pluripotent stem cells in Brown et al. 2011, Teo et al. 2011) bind the promoter of the SOX17 gene. EOMES, TBXT, MIXL1 (inferred from mouse homologs), and GATA6 that are expressed in the primitive streak bind the SOX17 promoter (Chia et al. 2019). FOXA2 and GATA4, endodermal transcription factors, bind a distal enhancer element that may interact with a downstream transcription start site of the SOX17 gene (inferred from mouse homologs).
Literature References
PubMed ID Title Journal Year
30629940 GATA6 Cooperates with EOMES/SMAD2/3 to Deploy the Gene Regulatory Network Governing Human Definitive Endoderm and Pancreas Formation

Chia, CY, Madrigal, P, Denil, SLIJ, Martinez, I, Garcia-Bernardo, J, El-Khairi, R, Chhatriwala, M, Shepherd, MH, Hattersley, AT, Dunn, NR, Vallier, L

Stem Cell Reports 2019
21630377 Activin/Nodal signaling controls divergent transcriptional networks in human embryonic stem cells and in endoderm progenitors

Brown, S, Teo, A, Pauklin, S, Hannan, N, Cho, CH, Lim, B, Vardy, L, Dunn, NR, Trotter, M, Pedersen, R, Vallier, L

Stem Cells 2011
21245162 Pluripotency factors regulate definitive endoderm specification through eomesodermin

Teo, AK, Arnold, SJ, Trotter, MW, Brown, S, Ang, LT, Chng, Z, Robertson, EJ, Dunn, NR, Vallier, L

Genes Dev. 2011
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Tcf7l2:Ctnnb1, Foxa2, Mixl1, and Gata4 bind the Sox17 gene (Mus musculus)
Authored
May, B  (2023-01-08)
Reviewed
Salehin, N  (2023-02-28)
Tam, PPL  (2023-02-28)
Created
May, B  (2023-01-20)
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