Reactome | Expression of EOMES in the primitive streak

Expression of EOMES in the primitive streak

Stable Identifier

R-HSA-452353

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Expression of EOMES in the primitive streak

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The Eomesodermin (EOMES) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. EOMES is required for formation of mesoderm. In embryonic stem cells, pluripotency factors POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the EOMES gene (Boyer et al. 2005). OCT4 and SOX2 repress EOMES transcription (Babaie et al. 2007, Teo et al. 2011) while NANOG positively regulates EOMES expression (Teo et al. 2011). During gastrulation EOMES is expressed in the posterior epiblast, in the primitive streak, and in mesoderm and definitive endoderm progentiors (inferred from the mouse homolog, inferred from the non-human primate Macaca fascicularis in Nakamura et al. 2016, Sasaki et al. 2016). EOMES-expressing cells are present in anterior mesoderm derivatives and are excluded from posterior mesoderm derivatives (inferred from the mouse homolog). Expression of EOMES is seen in human embryonic stem cells (Ginis et al. 2004 Tsankov et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25693565	Transcription factor binding dynamics during human ES cell differentiation Ziller, MJ, Gnirke, A, Gu, H, Amit, I, Meissner, A, Akopian, V, Tsankov, AM, Donaghey, J	Nature	2015
15110706	Differences between human and mouse embryonic stem cells Itskovitz-Eldor, J, Miura, T, Amit, M, Thies, S, Rao, MS, Carpenter, MK, Hoke, A, Gerecht-Nir, S, Ginis, I, Luo, Y, Brandenberger, R	Dev Biol	2004
17068183	Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J	Stem Cells	2007
21245162	Pluripotency factors regulate definitive endoderm specification through eomesodermin Dunn, NR, Chng, Z, Trotter, MW, Vallier, L, Teo, AK, Ang, LT, Brown, S, Arnold, SJ, Robertson, EJ	Genes Dev.	2011