Expression of EOMES in the primitive streak

Stable Identifier
Reaction [omitted]
Homo sapiens
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The Eomesodermin (EOMES) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. EOMES is required for formation of mesoderm. In embryonic stem cells, pluripotency factors POU5F1 (OCT4), SOX2, and NANOG bind the promoter of the EOMES gene (Boyer et al. 2005). OCT4 and SOX2 repress EOMES transcription (Babaie et al. 2007, Teo et al. 2011) while NANOG positively regulates EOMES expression (Teo et al. 2011). During gastrulation EOMES is expressed in the posterior epiblast, in the primitive streak, and in mesoderm and definitive endoderm progentiors (inferred from the mouse homolog, inferred from the non-human primate Macaca fascicularis in Nakamura et al. 2016, Sasaki et al. 2016). EOMES-expressing cells are present in anterior mesoderm derivatives and are excluded from posterior mesoderm derivatives (inferred from the mouse homolog). Expression of EOMES is seen in human embryonic stem cells (Ginis et al. 2004 Tsankov et al. 2015).
Literature References
PubMed ID Title Journal Year
25693565 Transcription factor binding dynamics during human ES cell differentiation

Ziller, MJ, Gnirke, A, Gu, H, Amit, I, Meissner, A, Akopian, V, Tsankov, AM, Donaghey, J

Nature 2015
15110706 Differences between human and mouse embryonic stem cells

Itskovitz-Eldor, J, Miura, T, Amit, M, Thies, S, Rao, MS, Carpenter, MK, Hoke, A, Gerecht-Nir, S, Ginis, I, Luo, Y, Brandenberger, R

Dev Biol 2004
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
21245162 Pluripotency factors regulate definitive endoderm specification through eomesodermin

Dunn, NR, Chng, Z, Trotter, MW, Vallier, L, Teo, AK, Ang, LT, Brown, S, Arnold, SJ, Robertson, EJ

Genes Dev. 2011
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