Acetylcholine binds Muscarinic Acetylcholine Receptor M3

Stable Identifier
Reaction [binding]
Homo sapiens
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Intrapancreatic parasympathetic (vagal) nerve endings release acetylcholine during preabsorptive and absorptive phases of feeding. The acetylcholine binds Muscarinic Acetylcholine Receptor M3 on pancreatic islet beta cells (inferred from experiments with knockout mice).

Literature References
PubMed ID Title Journal Year
16753580 A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

Li, JH, Jeon, J, Han, SJ, Deng, C, Mears, D, Wess, J, Lu, H, Hamdan, FF, Heard, T, Cui, Y, Li, B, Gautam, D

Cell Metab 2006
17919190 Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis

Li, JH, Jeon, J, Han, SJ, Mears, D, Wess, J, Hamdan, FF, Cui, Y, Duttaroy, A, Gautam, D

Diabetes Obes Metab 2007
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
11588141 Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

Gilon, P, Henquin, JC

Endocr Rev 2001
Inferred From
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