Reactome | Acetylcholine binds Muscarinic Acetylcholine Receptor M3

Acetylcholine binds Muscarinic Acetylcholine Receptor M3

Stable Identifier

R-HSA-400012

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Acetylcholine binds Muscarinic Acetylcholine Receptor M3

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Intrapancreatic parasympathetic (vagal) nerve endings release acetylcholine during preabsorptive and absorptive phases of feeding. The acetylcholine binds Muscarinic Acetylcholine Receptor M3 on pancreatic islet beta cells (inferred from experiments with knockout mice).

Literature References

PubMed ID	Title	Journal	Year
16753580	A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo Li, JH, Jeon, J, Han, SJ, Deng, C, Mears, D, Wess, J, Lu, H, Hamdan, FF, Heard, T, Cui, Y, Li, B, Gautam, D	Cell Metab	2006
17919190	Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis Li, JH, Jeon, J, Han, SJ, Mears, D, Wess, J, Hamdan, FF, Cui, Y, Duttaroy, A, Gautam, D	Diabetes Obes Metab	2007
17900700	G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes Ahren, B, Winzell, MS	Pharmacol Ther	2007
11588141	Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function Gilon, P, Henquin, JC	Endocr Rev	2001