Acetylcholine binds Muscarinic Acetylcholine Receptor M3

Stable Identifier
R-HSA-400012
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Intrapancreatic parasympathetic (vagal) nerve endings release acetylcholine during preabsorptive and absorptive phases of feeding. The acetylcholine binds Muscarinic Acetylcholine Receptor M3 on pancreatic islet beta cells (inferred from experiments with knockout mice).

Literature References
PubMed ID Title Journal Year
17919190 Role of the M3 muscarinic acetylcholine receptor in beta-cell function and glucose homeostasis

Gautam, D, Han, SJ, Duttaroy, A, Mears, D, Hamdan, FF, Li, JH, Cui, Y, Jeon, J, Wess, J

Diabetes Obes Metab 2007
16753580 A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo

Gautam, D, Han, SJ, Hamdan, FF, Jeon, J, Li, B, Li, JH, Cui, Y, Mears, D, Lu, H, Deng, C, Heard, T, Wess, J

Cell Metab 2006
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Winzell, MS, Ahren, B

Pharmacol Ther 2007
11588141 Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

Gilon, P, Henquin, JC

Endocr Rev 2001
Participants
Participant Of
Inferred From
Authored
Reviewed
Created