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CHRM5 [plasma membrane]
Stable Identifier
R-HSA-390678
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
M5, Muscarinic acetylcholine receptor M5, ACM5_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Muscarinic acetylcholine receptors (Homo sapiens)
CHRM1,3,5 bind CHRM1,3,5 antagonists (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
CHRM1,3,5:CHRM1,3,5 antagonists [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
CHRM1,3,5 bind acetylcholine (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
CHRM1,3,5 [plasma membrane] (Homo sapiens)
CHRM5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08912 CHRM5
Gene Names
CHRM5
Chain
chain:1-532
Reference Genes
BioGPS Gene:1133 CHRM5
COSMIC (genes):CHRM5 CHRM5
CTD Gene:1133 CHRM5
dbSNP Gene:1133 CHRM5
ENSEMBL:ENSG00000184984.10 CHRM5
HGNC:1954 CHRM5
KEGG Gene (Homo sapiens):1133 CHRM5
Monarch:1133 CHRM5
NCBI Gene:1133 CHRM5
OMIM:118496 CHRM5
UCSC:P08912 CHRM5
Reference Transcript
RefSeq:NM_012125.3 CHRM5
RefSeq:NM_001320917.1 CHRM5
Other Identifiers
0003440577
1133
11734327_a_at
11747024_a_at
16799077
221347_PM_at
221347_at
3588038
3588045
3588050
3588051
3588052
3588053
3588055
7982497
A_23_P117873
GE58087
GO:0001696
GO:0004435
GO:0004930
GO:0004993
GO:0005515
GO:0005886
GO:0005887
GO:0006629
GO:0007165
GO:0007186
GO:0007187
GO:0007197
GO:0007213
GO:0007268
GO:0015872
GO:0016020
GO:0016021
GO:0016787
GO:0016907
GO:0019226
GO:0022600
GO:0023052
GO:0030054
GO:0030425
GO:0030594
GO:0045202
GO:0045211
GO:0050877
GO:0060089
GO:0060304
GO:0070161
GO:0095500
GO:0098664
HMNXSV003054975
ILMN_1746646
M80333_at
PH_hs_0029495
TC15000231.hg
g7108335_3p_at
Participates
as a member of
CHRM1,3,5 [plasma membrane] (Homo sapiens)
Inferred To
chrm5 [plasma membrane]
(Danio rerio)
chrm5 [plasma membrane]
(Xenopus tropicalis)
gar-2 [plasma membrane]
(Caenorhabditis elegans)
CHRM5 [plasma membrane]
(Bos taurus)
CHRM5 [plasma membrane]
(Canis familiaris)
CHRM5 [plasma membrane]
(Gallus gallus)
CHRM5 [plasma membrane]
(Sus scrofa)
Chrm5 [plasma membrane]
(Mus musculus)
Chrm5 [plasma membrane]
(Rattus norvegicus)
gar-3 [plasma membrane]
(Caenorhabditis elegans)
mAChR-B [plasma membrane]
(Drosophila melanogaster)
Homologues of CHRM5 [plasma membrane]
(Caenorhabditis elegans)
Homologues of CHRM5 [plasma membrane]
(Drosophila melanogaster)
mAChR-A [plasma membrane]
(Drosophila melanogaster)
gar-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_036257.1
,
NP_001307846.1
ZINC - World Drugs
ACM5_HUMAN
Guide to Pharmacology - Targets
17
OpenTargets
ENSG00000184984
ZINC - FDA approved
ACM5_HUMAN
ZINC - Substances
ACM5_HUMAN
ZINC - Biogenic
ACM5_HUMAN
ZINC target
P08912
PRO
P08912
PDB
6OL9
ZINC - Investigational
ACM5_HUMAN
ZINC - Metabolites
ACM5_HUMAN
HPA
ENSG00000184984-CHRM5
GeneCards
P08912
Ensembl
ENSP00000453745
,
ENST00000383263
,
ENSG00000184984
,
ENST00000557872
,
ENSP00000372750
Pharos - Targets
P08912
ZINC - Predictions - Purchasable
ACM5_HUMAN
HMDB Protein
HMDBP10812
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20309 CHRM3
1
CHRM3 [plasma membrane]
(R-HSA-399994)
0.589
7
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