Reactome | CHRM5 [plasma membrane]

CHRM5 [plasma membrane]

Stable Identifier

R-HSA-390678

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

M5, Muscarinic acetylcholine receptor M5, ACM5_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Muscarinic acetylcholine receptors (Homo sapiens)
        
        CHRM1,3,5 bind CHRM1,3,5 antagonists (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:CHRM1,3,5 antagonists [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 bind acetylcholine (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5:AcCho [plasma membrane] (Homo sapiens)
        
        CHRM1,3,5 [plasma membrane] (Homo sapiens)
        
        CHRM5 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08912 CHRM5

Gene Names

CHRM5

Chain

chain:1-532

Reference Genes

BioGPS Gene:1133 CHRM5

COSMIC (genes):CHRM5 CHRM5

CTD Gene:1133 CHRM5

dbSNP Gene:1133 CHRM5

ENSEMBL:ENSG00000184984.10 CHRM5

HGNC:1954 CHRM5

KEGG Gene (Homo sapiens):1133 CHRM5

Monarch:1133 CHRM5

NCBI Gene:1133 CHRM5

OMIM:118496 CHRM5

UCSC:P08912 CHRM5

Reference Transcript

Other Identifiers

0003440577

1133

11734327_a_at

11747024_a_at

16799077

221347_PM_at

221347_at

3588038

3588045

3588050

3588051

3588052

3588053

3588055

7982497

A_23_P117873

GE58087

GO:0001696

GO:0004435

GO:0004930

GO:0004993

GO:0005515

GO:0005886

GO:0005887

GO:0006629

GO:0007165

GO:0007186

GO:0007187

GO:0007197

GO:0007213

GO:0007268

GO:0015872

GO:0016020

GO:0016021

GO:0016787

GO:0016907

GO:0019226

GO:0022600

GO:0023052

GO:0030054

GO:0030425

GO:0030594

GO:0045202

GO:0045211

GO:0050877

GO:0060089

GO:0060304

GO:0070161

GO:0095500

GO:0098664

HMNXSV003054975

ILMN_1746646

M80333_at

PH_hs_0029495

TC15000231.hg

g7108335_3p_at

Participates

as a member of

CHRM1,3,5 [plasma membrane] (Homo sapiens)

Inferred To

chrm5 [plasma membrane] (Danio rerio)

chrm5 [plasma membrane] (Xenopus tropicalis)

gar-2 [plasma membrane] (Caenorhabditis elegans)

CHRM5 [plasma membrane] (Bos taurus)

CHRM5 [plasma membrane] (Canis familiaris)

CHRM5 [plasma membrane] (Gallus gallus)

CHRM5 [plasma membrane] (Sus scrofa)

Chrm5 [plasma membrane] (Mus musculus)

Chrm5 [plasma membrane] (Rattus norvegicus)

gar-3 [plasma membrane] (Caenorhabditis elegans)

mAChR-B [plasma membrane] (Drosophila melanogaster)

Homologues of CHRM5 [plasma membrane] (Caenorhabditis elegans)

Homologues of CHRM5 [plasma membrane] (Drosophila melanogaster)

mAChR-A [plasma membrane] (Drosophila melanogaster)

gar-1 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_036257.1, NP_001307846.1

ZINC - World Drugs

ACM5_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000184984

ZINC - FDA approved

ACM5_HUMAN

ZINC - Substances

ACM5_HUMAN

ZINC - Biogenic

ACM5_HUMAN

ZINC target

P08912

PRO

P08912

PDB

6OL9

ZINC - Investigational

ACM5_HUMAN

ZINC - Metabolites

ACM5_HUMAN

HPA

ENSG00000184984-CHRM5

GeneCards

P08912

Ensembl

ENSP00000453745, ENST00000383263, ENSG00000184984, ENST00000557872, ENSP00000372750

Pharos - Targets

P08912

ZINC - Predictions - Purchasable

ACM5_HUMAN

HMDB Protein

HMDBP10812

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20309 CHRM3	1	CHRM3 [plasma membrane] (R-HSA-399994)	0.589	7