Reactome | CHRM3 [plasma membrane]

CHRM3 [plasma membrane]

Stable Identifier

R-CFA-399994

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

CHRM3, A0A8I3N190

Locations in the PathwayBrowser

Expand all

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (q) signalling events (Canis familiaris)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gq complex dissociates (Canis familiaris)
        
        GPCRs that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Amine ligand-binding receptors (Canis familiaris)
        
        Muscarinic acetylcholine receptors (Canis familiaris)
        
        CHRM1,3,5 bind CHRM1,3,5 antagonists (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5:CHRM1,3,5 antagonists [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5 bind acetylcholine (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5:AcCho [plasma membrane] (Canis familiaris)
        
        CHRM1,3,5 [plasma membrane] (Canis familiaris)
        
        CHRM3 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N190

Gene Names

CHRM3

Reference Genes

BioGPS Gene:403827 CHRM3

ENSEMBL:ENSCAFG00845002175.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845002175.1 CHRM3

KEGG Gene (Canis lupus familiaris):403827 CHRM3

Monarch:403827 CHRM3

NCBI Gene:403827 CHRM3

Reference Transcript

Other Identifiers

403827

Cfa.12801.1.A1_s_at

Cfa.12801.1.A1_x_at

Cfa.3691.1.S1_s_at

GO:0003012

GO:0004930

GO:0005886

GO:0007186

GO:0016020

GO:0016907

GO:0022600

GO:0023052

GO:0045987

GO:0046541

GO:0060089

Participates

as a member of

CHRM1,3,5 [plasma membrane] (Canis familiaris)

Inferred From

CHRM3 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_005618825.1, XP_013968187.1, XP_005618826.1, XP_005618819.1, XP_005618821.1, XP_013968188.1, XP_005618820.1, XP_005618823.1, XP_005618827.1, XP_013968189.1, XP_005618818.1, XP_005618828.1, XP_005618817.1

OpenTargets

ENSG00000133019

Ensembl

ENSCAFG00845002175, ENSCAFP00845003039, ENSCAFP00845003034, ENSCAFT00845003811, ENSCAFT00845003817