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p-Y311,Y316,Y330-EFNB2 [plasma membrane]
Stable Identifier
R-HSA-3928387
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-Ephrin-B2, EFNB2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
Ephrin signaling (Homo sapiens)
EFNB:GRB4 binds GIT1 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
GIT1 binds bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
PAK binds RAC and bPIX (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
PAKs autophosphorylate (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
PAKs phosphorylate MLC (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:p-PAK1,3 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
SFKs phosphorylate EFNBs (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
bPIX exchanges GTP for GDP on RAC, activating it (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
p-EFNB binds GRB4 (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4 [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs:SRC,FYN [plasma membrane] (Homo sapiens)
EPHBs:p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
p-Y311,Y316,Y330-EFNB2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52799 EFNB2
Gene Names
EFNB2, EPLG5, HTKL, LERK5
Chain
signal peptide:1-27, chain:28-333
Reference Genes
BioGPS Gene:1948 EFNB2
COSMIC (genes):EFNB2 EFNB2
CTD Gene:1948 EFNB2
dbSNP Gene:1948 EFNB2
ENSEMBL:ENSG00000125266 EFNB2
HGNC:3227 EFNB2
KEGG:hsa:1948 EFNB2
Monarch:1948 EFNB2
NCBI Gene:1948 EFNB2
OMIM:600527 EFNB2
UCSC:P52799 EFNB2
Reference Transcript
RefSeq:NM_004093.3 EFNB2
Other Identifiers
11720402_at
11720403_at
11720404_at
11720405_at
16780859
1948
202668_PM_at
202668_at
202669_PM_s_at
202669_s_at
34334_at
34335_at
3524567
3524569
3524571
3524572
3524573
3524574
3524575
3524576
3524577
3524578
3524579
3524580
3524581
3524582
3524588
3524589
3524590
3524604
3524605
3524606
3524607
3524608
3524609
3524611
7972713
A_23_P428139
A_24_P355944
GE59472
GO:0001525
GO:0001618
GO:0001945
GO:0002042
GO:0002376
GO:0005102
GO:0005515
GO:0005886
GO:0005912
GO:0005925
GO:0007155
GO:0007267
GO:0007399
GO:0007411
GO:0008284
GO:0009653
GO:0009887
GO:0010839
GO:0010977
GO:0016020
GO:0023052
GO:0030154
GO:0031295
GO:0034330
GO:0034332
GO:0042734
GO:0043616
GO:0046718
GO:0046875
GO:0048013
GO:0048514
GO:0048845
GO:0048856
GO:0048870
GO:0050920
GO:0070161
GO:0072178
GO:0098685
GO:0098839
GO:0098978
GO:0099072
GO:0099149
GO:1903849
GO:2000727
HMNXSV003057862
Hs.30942.0.S3_3p_at
ILMN_1703852
PH_hs_0002640
TC13000860.hg
U81262_at
g902370_3p_a_at
Participates
as a member of
p-3Y-EFNBs [plasma membrane] (Homo sapiens)
Other forms of this molecule
EFNB2 [plasma membrane]
Inferred To
phospho-efnB2 [plasma membrane]
(Canis familiaris)
phospho-Efnb2 [plasma membrane]
(Mus musculus)
phospho-efn-4 [plasma membrane]
(Caenorhabditis elegans)
Homologues of p-Y311,Y316,Y330-EFNB2 [plasma membrane]
(Caenorhabditis elegans)
phospho-EFNB2 [plasma membrane]
(Bos taurus)
phospho-EFNB2 [plasma membrane]
(Gallus gallus)
phospho-efn-2 [plasma membrane]
(Caenorhabditis elegans)
phospho-Ephrin [plasma membrane]
(Drosophila melanogaster)
phospho-efnb2b [plasma membrane]
(Danio rerio)
phospho-efn-3 [plasma membrane]
(Caenorhabditis elegans)
phospho-vab-2 [plasma membrane]
(Caenorhabditis elegans)
phospho-efnb2 [plasma membrane]
(Xenopus tropicalis)
phospho-p-Y311,Y316,Y330-EFNB2 [plasma membrane]
(Rattus norvegicus)
phospho-p-Y311,Y316,Y330-EFNB2 [plasma membrane]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 311
Coordinate
311
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 316
Coordinate
316
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 330
Coordinate
330
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_004084.1
ENSEMBL
ENST00000646441
,
ENSP00000493716
OpenTargets
ENSG00000125266
HPA
ENSG00000125266-EFNB2
PRO
P52799
Pharos - Targets
P52799
GlyGen
P52799
PDB
2VSM
,
6P7Y
,
2VSK
,
6PDL
,
2WO2
,
4UF7
,
3GXU
,
2HLE
,
2I85
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54764 EPHA4
2
p-Y596,Y602-EPHA4 [plasma membrane]
(R-HSA-3928352)
EPHA4 [plasma membrane]
(R-HSA-2682325)
0.65
4
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.597
7
UniProt:P29323 EPHB2
6
EPHB2 (?-?) [plasma membrane]
(R-HSA-3928394)
EPHB2 (?-1055) [cytosol]
(R-HSA-3928432)
EPHB2 (?-1055) [plasma membrane]
(R-HSA-3928386)
EPHB2 (19-?) [extracellular region]
(R-HSA-3928436)
EPHB2 [plasma membrane]
(R-HSA-443809)
p-Y596,Y602-EPHB2 [plasma membrane]
(R-HSA-3928375)
0.527
2
UniProt:P29597 TYK2
5
p-Y1054-TYK2 [cytosol]
(R-HSA-1112598)
p-Y1054,Y1055-TYK2 [cytosol]
(R-HSA-909682)
TYK2 [cytosol]
(R-HSA-877348)
p-Y-TYK2 [cytosol]
(R-HSA-6784366)
p-TYK2 [cytosol]
(R-HSA-8950424)
0.527
2
UniProt:Q15058 KIF14
1
KIF14 [cytosol]
(R-HSA-1629804)
0.527
2
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