Reactome | PolyUb,p-8Y-CSF1R [plasma membrane]

PolyUb,p-8Y-CSF1R [plasma membrane]

Stable Identifier

R-HSA-389142

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phosphorylated macrophage colony stimulating factor I receptor precursor

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External Reference Information

External Reference

UniProt:P07333 CSF1R

Gene Names

CSF1R, FMS

Chain

signal peptide:1-19, chain:20-972

Reference Genes

BioGPS Gene:1436 CSF1R

COSMIC (genes):CSF1R CSF1R

CTD Gene:1436 CSF1R

dbSNP Gene:1436 CSF1R

ENSEMBL:ENSG00000182578 CSF1R

ENSEMBL_homo_sapiens_GENE:ENSG00000182578.14 CSF1R

HGNC:2433 CSF1R

KEGG Gene (Homo sapiens):1436 CSF1R

Monarch:1436 CSF1R

NCBI Gene:1436 CSF1R

OMIM:164770 CSF1R

UCSC:P07333 CSF1R

Reference Transcript

Other Identifiers

11716993_a_at

11749817_a_at

11752273_a_at

1436

160022_at

17001545

1864_at

203104_PM_at

203104_at

2881188

2881189

2881190

2881191

2881192

2881194

2881195

2881196

2881197

2881198

2881199

2881200

2881202

2881203

2881204

2881205

2881206

2881209

2881213

2881214

2881215

2881216

2881217

2881218

2881219

2881220

2881221

2881222

2881224

2881227

2881228

2881229

2881230

2881231

2881232

2881233

2881234

2881238

2881242

8115076

A_23_P110791

GE59653

GO:0000166

GO:0001934

GO:0002376

GO:0002931

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005011

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005886

GO:0006468

GO:0006954

GO:0007010

GO:0007165

GO:0007169

GO:0007411

GO:0008283

GO:0008284

GO:0008285

GO:0008360

GO:0009986

GO:0010759

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019221

GO:0019838

GO:0019903

GO:0019955

GO:0021772

GO:0021879

GO:0023052

GO:0030097

GO:0030154

GO:0030224

GO:0030225

GO:0030316

GO:0030335

GO:0031401

GO:0031529

GO:0032722

GO:0032956

GO:0034330

GO:0036006

GO:0036211

GO:0038145

GO:0042531

GO:0042803

GO:0043066

GO:0043226

GO:0043231

GO:0043235

GO:0043408

GO:0044794

GO:0045087

GO:0045124

GO:0045217

GO:0045937

GO:0046777

GO:0048584

GO:0048856

GO:0048870

GO:0051897

GO:0060089

GO:0060603

GO:0061098

GO:0061518

GO:0070374

GO:0071345

GO:0098542

GO:0120041

GO:0140096

GO:1905521

GO:1990682

GO:2000147

HMNXSV003057391

ILMN_1686623

PH_hs_0010440

TC05001932.hg

TC05003302.hg

X03663_at

g4885158_3p_at

Participates

as a component of

PolyUb,p-8Y-CSF1R dimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

PolyUb,p-Y561-CSF1R [plasma membrane]

p-Y561-CSF1R [plasma membrane]

CSF1R [plasma membrane]

Modified Residues

Name

O4'-phospho-L-tyrosine at 699

Coordinate

699

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 708

Coordinate

708

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 723

Coordinate

723

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 809

Coordinate

809

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 561

Coordinate

561

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 546

Coordinate

546

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 923

Coordinate

923

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 969

Coordinate

969

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001275634.1, NP_005202.2

ZINC - World Drugs

CSF1R_HUMAN

Guide to Pharmacology - Targets

1806

OpenTargets

ENSG00000182578

ZINC - FDA approved

CSF1R_HUMAN

ZINC - Substances

CSF1R_HUMAN

ZINC target

P07333

ZINC - Biogenic

CSF1R_HUMAN

PRO

P07333

PDB

3KRJ, 4WRM, 6T2W, 7MFC, 4R7H, 8CGC, 2OGV, 4HW7, 3LCO, 3KRL, 3DPK, 3BEA, 6WXJ, 2I1M, 4WRL, 4R7I, 2I0Y, 4LIQ, 3LCD, 6N33, 6IG8, 4DKD, 2I0V

ZINC - Investigational

CSF1R_HUMAN

IntEnz

2.7.10.1

GeneCards

P07333

HPA

ENSG00000182578-CSF1R

Ensembl

ENSP00000501699, ENST00000543093, ENST00000286301, ENSP00000445282, ENST00000675795, ENSG00000182578, ENSP00000286301

Pharos - Targets

P07333

ZINC - Predictions - Purchasable

CSF1R_HUMAN

Orphanet

21593

HMDB Protein

HMDBP01314

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09603 CSF1	4	CSF1 [endoplasmic reticulum lumen] (R-HSA-8956778) p-CSF1 [endoplasmic reticulum lumen] (R-HSA-8956881) CSF1 [extracellular region] (R-HSA-9009484) CSF1 [plasma membrane] (R-HSA-389148)	0.884	13
UniProt:Q6ZMJ4-1 IL34			0.786	9
UniProt:Q15375 EPHA7	2	EPHA7 [plasma membrane] (R-HSA-2682337) p-Y608,Y614-EPHA7 [plasma membrane] (R-HSA-3928358)	0.499	2
UniProt:P29323 EPHB2	6	EPHB2 (?-?) [plasma membrane] (R-HSA-3928394) EPHB2 (?-1055) [cytosol] (R-HSA-3928432) EPHB2 (?-1055) [plasma membrane] (R-HSA-3928386) EPHB2 (19-?) [extracellular region] (R-HSA-3928436) EPHB2 [plasma membrane] (R-HSA-443809) p-Y596,Y602-EPHB2 [plasma membrane] (R-HSA-3928375)	0.499	2
UniProt:Q8CIH5 Plcg2	9	p-Y-Plcg2 [cytosol] (R-MMU-9029100) Plcg2 [cytosol] (R-MMU-5607628) phospho-Plcg2 [cytosol] (R-MMU-5607631) phospho-Plcg2 [plasma membrane] (R-MMU-5607640) phospho-Plcg2 [plasma membrane] (R-MMU-2685601) p-Y753,Y759-Plcg2 [cytosol] (R-MMU-5607654) phospho-Plcg2 [plasma membrane] (R-MMU-984816) Plcg2 [plasma membrane] (R-MMU-114601) phospho-Plcg2 [plasma membrane] (R-MMU-114602)	0.482	2

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