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IGFALS [extracellular region]
Stable Identifier
R-HSA-381498
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IGFBP Complex Acid Labile Subunit, ALS_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
Formation of the IGF:IGFBP3:ALS complex (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)
IGF:IGFBP5:ALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)
IGF:IGFBP5:ALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
IGFALS [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35858 IGFALS
Gene Names
IGFALS, ALS
Chain
signal peptide:1-27, chain:28-605
Reference Genes
BioGPS Gene:3483 IGFALS
COSMIC (genes):IGFALS IGFALS
CTD Gene:3483 IGFALS
dbSNP Gene:3483 IGFALS
ENSEMBL:ENSG00000099769 IGFALS
HGNC:5468 IGFALS
KEGG:hsa:3483 IGFALS
Monarch:3483 IGFALS
NCBI Gene:3483 IGFALS
OMIM:601489 IGFALS
UCSC:P35858 IGFALS
Reference Transcript
RefSeq:NM_001146006.1 IGFALS
RefSeq:NM_004970.2 IGFALS
Other Identifiers
11740660_a_at
16822825
215712_PM_s_at
215712_s_at
3483
3676157
3676158
3676159
3676160
3676162
573_at
7998601
ADDON002383.hg
ADDON002834.hg
A_23_P14892
GE58121
GO:0005515
GO:0005520
GO:0005576
GO:0005615
GO:0007155
GO:0007165
GO:0030312
GO:0031012
GO:0042567
GO:0043226
GO:0070062
HMNXSV003055851
Hs.839.1.A1_3p_a_at
ILMN_2188966
M86826_at
PH_hs_0040074
TC16000761.hg
TC16001741.hg
Participates
as an output of
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Cathepsin G proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Plasmin proteolyzes IGF:IGFBP-3:ALS (Homo sapiens)
PAPP-A2 proteolyzes IGF:IGFBP5:ALS (Homo sapiens)
Thrombin proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
as an input of
Formation of the IGF:IGFBP5:ALS complex (Homo sapiens)
Formation of the IGF:IGFBP3:ALS complex (Homo sapiens)
as a component of
IGF:IGFBP5:ALS [extracellular region] (Homo sapiens)
IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)
Inferred To
igfals [extracellular region]
(Danio rerio)
Igfals [extracellular region]
(Rattus norvegicus)
sma-10 [extracellular region]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENSG00000099769
,
ENST00000415638
,
ENST00000215539
,
ENSP00000215539
,
ENSP00000416683
OpenTargets
ENSG00000099769
GeneCards
IGFALS
HPA
ENSG00000099769-IGFALS
PRO
P35858
Pharos - Targets
P35858
Orphanet
IGFALS
PDB
7WRQ
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