Reactome | Cathepsin G proteolyzes IGF:IGFBP3:ALS

Cathepsin G proteolyzes IGF:IGFBP3:ALS

Stable Identifier

R-HSA-381500

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Cathepsin G cleaves IGFBP-3 between amino acids 168 and 169 and between amino acids 226 and 227, releasing IGF from the IGF:IGFBP-3:ALS Complex.

Literature References

PubMed ID	Title	Journal	Year
10512690	Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases Gibson, TL, Cohen, P	Growth Horm IGF Res	1999