Reactome | Cathepsin G proteolyzes IGF:IGFBP3:ALS

Cathepsin G proteolyzes IGF:IGFBP3:ALS

Stable Identifier

R-HSA-381500

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Cathepsin G cleaves IGFBP-3 between amino acids 168 and 169 and between amino acids 226 and 227, releasing IGF from the IGF:IGFBP-3:ALS Complex.

Literature References

PubMed ID	Title	Journal	Year
10512690	Inflammation-related neutrophil proteases, cathepsin G and elastase, function as insulin-like growth factor binding protein proteases Gibson, TL, Cohen, P	Growth Horm IGF Res	1999

Participants

Input

IGF:IGFBP3:ALS [extracellular region] (Homo sapiens)

Output

Participant Of

hasEvent

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Catalyst Activity

Title

serine-type endopeptidase activity of Cathepsin G [plasma membrane]

Physical Entity

Cathepsin G [plasma membrane]

Activity

serine-type endopeptidase activity (0004252)

Orthologous Events

Cathepsin G proteolyzes IGF:IGFBP3:ALS (Danio rerio)

Authored

May, B (2008-11-20)

Gopinathrao, G (2008-11-20)

Reviewed

D'Eustachio, P (2008-12-02)

Matthews, L (2008-12-02)

Gillespie, ME (2008-12-02)

Created

May, B (2008-11-20)