Plasmin proteolyzes IGF:IGFBP-3:ALS

Stable Identifier
Reaction [transition]
Homo sapiens
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Plasmin cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 124 and 125 and between amino acids 187 and 188, releasing IGF.

Literature References
PubMed ID Title Journal Year
7527330 Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells

Silve, C, Segovia, B, Rosato, R, Lalou, C, Binoux, M

Endocrinology 1994
7588299 Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3)

Angelloz-Nicoud, P, Binoux, M

Endocrinology 1995
8964575 Isolation and characterization of proteolytic fragments of insulin-like growth factor-binding protein-3

Lassarre, C, Lalou, C, Binoux, M

Horm Res 1996
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
10990447 Prostate carcinoma (PC-3) cell proliferation is stimulated by the 22-25-kDa proteolytic fragment (1-160) and inhibited by the 16-kDa fragment (1-95) of recombinant human insulin-like growth factor binding protein-3

Angelloz-Nicoud, P, Lalou, C, Binoux, M

Growth Horm IGF Res 1998
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
8894645 Recombinant human insulin-like growth factor (IGF) binding protein-3 stimulates prostate carcinoma cell proliferation via an IGF-dependent mechanism. Role of serine proteases

Harel, L, Angelloz-Nicoud, P, Binoux, M

Growth Regul 1996
8817670 Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth

Beers, T, Nunn, S, Katz, L, Rajah, R, Solberg, P, Cohen, P

Prog Growth Factor Res 1995
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
11739083 IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis

Knudtson, KL, Booth, BA, Bar, RS, Dake, BL, Boes, M

Am J Physiol Endocrinol Metab 2002
Catalyst Activity

serine-type endopeptidase activity of Plasmin [extracellular region]

Orthologous Events
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