Reactome | Plasmin proteolyzes IGF:IGFBP-3:ALS

Plasmin proteolyzes IGF:IGFBP-3:ALS

Stable Identifier

R-HSA-381461

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Plasmin cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 124 and 125 and between amino acids 187 and 188, releasing IGF.

Literature References

PubMed ID	Title	Journal	Year
7527330	Interactions between insulin-like growth factor-I (IGF-I) and the system of plasminogen activators and their inhibitors in the control of IGF-binding protein-3 production and proteolysis in human osteosarcoma cells Silve, C, Segovia, B, Rosato, R, Lalou, C, Binoux, M	Endocrinology	1994
7588299	Autocrine regulation of cell proliferation by the insulin-like growth factor (IGF) and IGF binding protein-3 protease system in a human prostate carcinoma cell line (PC-3) Angelloz-Nicoud, P, Binoux, M	Endocrinology	1995
8964575	Isolation and characterization of proteolytic fragments of insulin-like growth factor-binding protein-3 Lassarre, C, Lalou, C, Binoux, M	Horm Res	1996
12466191	Cellular actions of the insulin-like growth factor binding proteins Baxter, RC, Firth, SM	Endocr Rev	2002
10990447	Prostate carcinoma (PC-3) cell proliferation is stimulated by the 22-25-kDa proteolytic fragment (1-160) and inhibited by the 16-kDa fragment (1-95) of recombinant human insulin-like growth factor binding protein-3 Angelloz-Nicoud, P, Lalou, C, Binoux, M	Growth Horm IGF Res	1998
17047378	The role of insulin-like growth factor binding proteins Perks, C, Holly, J	Neuroendocrinology	2006
8894645	Recombinant human insulin-like growth factor (IGF) binding protein-3 stimulates prostate carcinoma cell proliferation via an IGF-dependent mechanism. Role of serine proteases Harel, L, Angelloz-Nicoud, P, Binoux, M	Growth Regul	1996
8817670	Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth Beers, T, Nunn, S, Katz, L, Rajah, R, Solberg, P, Cohen, P	Prog Growth Factor Res	1995
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
11739083	IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis Knudtson, KL, Booth, BA, Bar, RS, Dake, BL, Boes, M	Am J Physiol Endocrinol Metab	2002