Matrix Metalloprotease-1 and -2 cleave IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 126 and 127, releasing IGF. The reaction has been demonstrated in vivo.
Baxter, RC, Firth, SM
Perks, C, Holly, J
Beers, T, Nunn, S, Katz, L, Rajah, R, Solberg, P, Cohen, P
Mohan, S, Baylink, DJ
Nachajon, RV, Hakonarson, H, Rajah, R, Grunstein, MM, Cohen, P, Collins, MH
Nagase, H, Fowlkes, JL, Suzuki, K, Enghild, JJ
metalloendopeptidase activity of MMP1,2 [extracellular region]
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