Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS

Stable Identifier
Reaction [transition]
Homo sapiens
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Matrix Metalloprotease-1 and -2 cleave IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 126 and 127, releasing IGF. The reaction has been demonstrated in vivo.

Literature References
PubMed ID Title Journal Year
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
8817670 Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth

Beers, T, Nunn, S, Katz, L, Rajah, R, Solberg, P, Cohen, P

Prog Growth Factor Res 1995
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
9922210 Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle

Nachajon, RV, Hakonarson, H, Rajah, R, Grunstein, MM, Cohen, P, Collins, MH

Am J Respir Cell Mol Biol 1999
7523391 Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures

Nagase, H, Fowlkes, JL, Suzuki, K, Enghild, JJ

J Biol Chem 1994
Catalyst Activity

metalloendopeptidase activity of MMP1,2 [extracellular region]

Orthologous Events
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