Matrix Metalloprotease-1 and -2 cleave IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 126 and 127, releasing IGF. The reaction has been demonstrated in vivo.
Holly, J, Perks, C
Firth, SM, Baxter, RC
Rajah, R, Katz, L, Nunn, S, Solberg, P, Beers, T, Cohen, P
Mohan, S, Baylink, DJ
Rajah, R, Nachajon, RV, Collins, MH, Hakonarson, H, Grunstein, MM, Cohen, P
Fowlkes, JL, Enghild, JJ, Suzuki, K, Nagase, H
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