Reactome | Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS

Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS

Stable Identifier

R-HSA-381435

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

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Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS

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Matrix Metalloprotease-1 and -2 cleave IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 126 and 127, releasing IGF. The reaction has been demonstrated in vivo.

Literature References

PubMed ID	Title	Journal	Year
17047378	The role of insulin-like growth factor binding proteins Holly, J, Perks, C	Neuroendocrinology	2006
12466191	Cellular actions of the insulin-like growth factor binding proteins Firth, SM, Baxter, RC	Endocr Rev	2002
8817670	Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth Rajah, R, Katz, L, Nunn, S, Solberg, P, Beers, T, Cohen, P	Prog Growth Factor Res	1995
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
9922210	Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle Rajah, R, Nachajon, RV, Collins, MH, Hakonarson, H, Grunstein, MM, Cohen, P	Am J Respir Cell Mol Biol	1999
7523391	Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures Fowlkes, JL, Enghild, JJ, Suzuki, K, Nagase, H	J Biol Chem	1994