Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS

Stable Identifier
R-HSA-381435
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
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Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS
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Matrix Metalloprotease-1 and -2 cleave IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 126 and 127, releasing IGF. The reaction has been demonstrated in vivo.

Literature References
PubMed ID Title Journal Year
17047378 The role of insulin-like growth factor binding proteins

Holly, J, Perks, C

Neuroendocrinology 2006
12466191 Cellular actions of the insulin-like growth factor binding proteins

Firth, SM, Baxter, RC

Endocr Rev 2002
8817670 Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth

Rajah, R, Katz, L, Nunn, S, Solberg, P, Beers, T, Cohen, P

Prog Growth Factor Res 1995
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
9922210 Elevated levels of the IGF-binding protein protease MMP-1 in asthmatic airway smooth muscle

Rajah, R, Nachajon, RV, Collins, MH, Hakonarson, H, Grunstein, MM, Cohen, P

Am J Respir Cell Mol Biol 1999
7523391 Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures

Fowlkes, JL, Enghild, JJ, Suzuki, K, Nagase, H

J Biol Chem 1994
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MMP1,2 [extracellular region]
Physical Entity
MMP1,2 [extracellular region]
Activity
metalloendopeptidase activity (0004222)
Orthologous Events
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Danio rerio)
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Rattus norvegicus)
Reviewed
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Gillespie, ME  (2008-12-02)
Created
May, B  (2008-11-20)