Both Pregnancy Associated Plasma Protein A (PAPP-A) and A2 (PAPP-A2) cleave IGFBP-5 in the IGF:IGFBP-5:ALS Complex between amino acids 163 and 164, releasing IGF. PPAP-A has also been shown to cleave IGFBP-5 that is not complexed with IGF.
Holly, J, Perks, C
Firth, SM, Baxter, RC
Laursen, LS, Overgaard, MT, Søe, R, Boldt, HB, Sottrup-Jensen, L, Giudice, LC, Conover, CA, Oxvig, C
Mohan, S, Baylink, DJ
Baxter, RC, Meka, S, Firth, SM
Overgaard, MT, Boldt, HB, Laursen, LS, Sottrup-Jensen, L, Conover, CA, Oxvig, C
Schneider, MR, Zhou, R, Hoeflich, A, Krebs, O, Schmidt, J, Mohan, S, Wolf, E, Lahm, H
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