PAPP-A2 proteolyzes IGF:IGFBP5:ALS

Stable Identifier
Reaction [transition]
Homo sapiens
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Both Pregnancy Associated Plasma Protein A (PAPP-A) and A2 (PAPP-A2) cleave IGFBP-5 in the IGF:IGFBP-5:ALS Complex between amino acids 163 and 164, releasing IGF. PPAP-A has also been shown to cleave IGFBP-5 that is not complexed with IGF.

Literature References
PubMed ID Title Journal Year
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
11522292 Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A

Conover, CA, Sottrup-Jensen, L, Overgaard, MT, Boldt, HB, Oxvig, C, Laursen, LS, Giudice, LC, Søe, R

FEBS Lett 2001
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
11788658 Molecular distribution of IGF binding protein-5 in human serum

Baxter, RC, Firth, SM, Meka, S

J Clin Endocrinol Metab 2002
11264294 Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase

Conover, CA, Sottrup-Jensen, L, Overgaard, MT, Boldt, HB, Oxvig, C, Laursen, LS

J Biol Chem 2001
11606061 Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells

Schmidt, J, Schneider, MR, Mohan, S, Wolf, E, Lahm, H, Zhou, R, Hoeflich, A, Krebs, O

Biochem Biophys Res Commun 2001
Catalyst Activity

metalloendopeptidase activity of PAPPA,PAPPA2 [extracellular region]

Orthologous Events
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