Reactome | PAPP-A2 proteolyzes IGF:IGFBP5:ALS

PAPP-A2 proteolyzes IGF:IGFBP5:ALS

Stable Identifier

R-HSA-381537

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Both Pregnancy Associated Plasma Protein A (PAPP-A) and A2 (PAPP-A2) cleave IGFBP-5 in the IGF:IGFBP-5:ALS Complex between amino acids 163 and 164, releasing IGF. PPAP-A has also been shown to cleave IGFBP-5 that is not complexed with IGF.

Literature References

PubMed ID	Title	Journal	Year
12466191	Cellular actions of the insulin-like growth factor binding proteins Baxter, RC, Firth, SM	Endocr Rev	2002
17047378	The role of insulin-like growth factor binding proteins Perks, C, Holly, J	Neuroendocrinology	2006
11522292	Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A Conover, CA, Sottrup-Jensen, L, Overgaard, MT, Boldt, HB, Oxvig, C, Laursen, LS, Giudice, LC, Søe, R	FEBS Lett	2001
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
11788658	Molecular distribution of IGF binding protein-5 in human serum Baxter, RC, Firth, SM, Meka, S	J Clin Endocrinol Metab	2002
11264294	Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase Conover, CA, Sottrup-Jensen, L, Overgaard, MT, Boldt, HB, Oxvig, C, Laursen, LS	J Biol Chem	2001
11606061	Insulin-like growth factor-binding protein-5 inhibits growth and induces differentiation of mouse osteosarcoma cells Schmidt, J, Schneider, MR, Mohan, S, Wolf, E, Lahm, H, Zhou, R, Hoeflich, A, Krebs, O	Biochem Biophys Res Commun	2001