Thrombin proteolyzes IGF:IGFBP3:ALS

Stable Identifier
Homo sapiens
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Thrombin cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 124 and 125 and between amino acids 233 and 234, releasing IGF.

Literature References
PubMed ID Title Journal Year
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
8817670 Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth

Beers, T, Nunn, S, Katz, L, Rajah, R, Solberg, P, Cohen, P

Prog Growth Factor Res 1995
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
11739083 IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis

Knudtson, KL, Booth, BA, Bar, RS, Dake, BL, Boes, M

Am J Physiol Endocrinol Metab 2002
Catalyst Activity

serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]

Orthologous Events
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