Reactome | Thrombin proteolyzes IGF:IGFBP3:ALS

Thrombin proteolyzes IGF:IGFBP3:ALS

Stable Identifier

R-HSA-381446

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Thrombin cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 124 and 125 and between amino acids 233 and 234, releasing IGF.

Literature References

PubMed ID	Title	Journal	Year
12466191	Cellular actions of the insulin-like growth factor binding proteins Firth, SM, Baxter, RC	Endocr Rev	2002
17047378	The role of insulin-like growth factor binding proteins Holly, J, Perks, C	Neuroendocrinology	2006
8817670	Insulin-like growth factor binding protein (IGFBP) proteases: functional regulators of cell growth Rajah, R, Katz, L, Nunn, S, Solberg, P, Beers, T, Cohen, P	Prog Growth Factor Res	1995
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
11739083	IGFBP-3 binding to endothelial cells inhibits plasmin and thrombin proteolysis Booth, BA, Boes, M, Dake, BL, Knudtson, KL, Bar, RS	Am J Physiol Endocrinol Metab	2002