Reactome | Formation of the IGF:IGFBP5:ALS complex

Formation of the IGF:IGFBP5:ALS complex

Stable Identifier

R-HSA-381545

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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IGFBP 5 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 5. IGFBP 5 also binds ALS via the central portion of IGFBP 5. About 55% of IGF:IGFBP 5 complexes contain ALS. IGFBP 5 is enriched in bone matrix and acts to stimulate IGF function. IGFBP 5 is cleaved by Pregnancy associated Plasma Protein A2 (PAPP A2), ADAM 9, complement C1s from smooth muscle, and thrombin. Only the cleavage site for PAPP A2 is known. About 55% of IGF:IGFBP 5 complexes contain ALS; 45% contain only IGF and IGFBP 5.

Literature References

PubMed ID	Title	Journal	Year
7683646	Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6 Bach, LA, Hsieh, S, Sakano, K, Fujiwara, H, Perdue, JF, Rechler, MM	J Biol Chem	1993
12466191	Cellular actions of the insulin-like growth factor binding proteins Firth, SM, Baxter, RC	Endocr Rev	2002
17047378	The role of insulin-like growth factor binding proteins Holly, J, Perks, C	Neuroendocrinology	2006
12379487	IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms Mohan, S, Baylink, DJ	J Endocrinol	2002
9786878	Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain Twigg, SM, Kiefer, MC, Zapf, J, Baxter, RC	J Biol Chem	1998
9497324	Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit Twigg, SM, Baxter, RC	J Biol Chem	1998
15126567	The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers Payet, LD, Firth, SM, Baxter, RC	J Clin Endocrinol Metab	2004
7689487	Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting Cianfarani, S, Frost, VJ, Savage, MO, Holly, JM	Experientia	1993
10614670	A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit Twigg, SM, Kiefer, MC, Zapf, J, Baxter, RC	Endocrinology	2000
8781553	Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography Bach, LA, Rechler, MM	Biochim Biophys Acta	1996
7519608	Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes Arai, T, Parker, A, Busby W, Jr, Clemmons, DR	J Biol Chem	1994
11788658	Molecular distribution of IGF binding protein-5 in human serum Baxter, RC, Meka, S, Firth, SM	J Clin Endocrinol Metab	2002
11316783	Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding Firth, SM, Clemmons, DR, Baxter, RC	Endocrinology	2001
10810289	Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6 Bond, JJ, Meka, S, Baxter, RC	J Endocrinol	2000