Formation of the IGF:IGFBP5:ALS complex

Stable Identifier
R-HSA-381545
Type
Reaction [binding]
Species
Homo sapiens
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IGFBP 5 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 5. IGFBP 5 also binds ALS via the central portion of IGFBP 5. About 55% of IGF:IGFBP 5 complexes contain ALS. IGFBP 5 is enriched in bone matrix and acts to stimulate IGF function. IGFBP 5 is cleaved by Pregnancy associated Plasma Protein A2 (PAPP A2), ADAM 9, complement C1s from smooth muscle, and thrombin. Only the cleavage site for PAPP A2 is known. About 55% of IGF:IGFBP 5 complexes contain ALS; 45% contain only IGF and IGFBP 5.

Literature References
PubMed ID Title Journal Year
9786878 Insulin-like growth factor-binding protein 5 complexes with the acid-labile subunit. Role of the carboxyl-terminal domain

Kiefer, MC, Zapf, J, Twigg, SM, Baxter, RC

J Biol Chem 1998
12379487 IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms

Mohan, S, Baylink, DJ

J Endocrinol 2002
11788658 Molecular distribution of IGF binding protein-5 in human serum

Baxter, RC, Firth, SM, Meka, S

J Clin Endocrinol Metab 2002
9497324 Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit

Twigg, SM, Baxter, RC

J Biol Chem 1998
10614670 A central domain binding site in insulin-like growth factor binding protein-5 for the acid-labile subunit

Kiefer, MC, Zapf, J, Twigg, SM, Baxter, RC

Endocrinology 2000
11316783 Mutagenesis of basic amino acids in the carboxyl-terminal region of insulin-like growth factor binding protein-5 affects acid-labile subunit binding

Baxter, RC, Clemmons, DR, Firth, SM

Endocrinology 2001
7689487 Glucose does not influence the insulin-like growth factor (JGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting

Savage, MO, Holly, JM, Frost, VJ, Cianfarani, S

Experientia 1993
10810289 Binding characteristics of pro-insulin-like growth factor-II from cancer patients: binary and ternary complex formation with IGF binding proteins-1 to -6

Baxter, RC, Meka, S, Bond, JJ

J Endocrinol 2000
8781553 Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography

Rechler, MM, Bach, LA

Biochim Biophys Acta 1996
15126567 The role of the acid-labile subunit in regulating insulin-like growth factor transport across human umbilical vein endothelial cell monolayers

Payet, LD, Baxter, RC, Firth, SM

J Clin Endocrinol Metab 2004
12466191 Cellular actions of the insulin-like growth factor binding proteins

Baxter, RC, Firth, SM

Endocr Rev 2002
7683646 Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6

Hsieh, S, Sakano, K, Rechler, MM, Fujiwara, H, Bach, LA, Perdue, JF

J Biol Chem 1993
7519608 Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes

Arai, T, Busby W, Jr, Parker, A, Clemmons, DR

J Biol Chem 1994
17047378 The role of insulin-like growth factor binding proteins

Perks, C, Holly, J

Neuroendocrinology 2006
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