Reactome | DCTN1-2 [cytosol]

DCTN1-2 [cytosol]

Stable Identifier

R-HSA-380301

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynactin 1 isoform 2

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN1-2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14203-2 DCTN1

Gene Names

DCTN1

Participates

as a component of

Inferred To

Dctn1 [cytosol] (Mus musculus)

Dctn1 [cytosol] (Rattus norvegicus)

DCTN1 [cytosol] (Bos taurus)

DCTN1 [cytosol] (Canis familiaris)

DCTN1 [cytosol] (Sus scrofa)

DCTN1-2 [cytosol] (Gallus gallus)

Ghost homologue of DCTN1-2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_075408.1, NP_004073.2, NP_001128513.1, NP_001128512.1, NP_001177765.1, NP_001177766.1

OpenTargets

ENSG00000204843

ENSEMBL

ENST00000409567, ENST00000409438, ENSP00000487724, ENSP00000377571, ENSP00000487279, ENST00000628224, ENSP00000387270, ENSG00000204843, ENST00000633691, ENSP00000386406, ENST00000394003, ENSP00000386843, ENST00000409240

HPA

ENSG00000204843-DCTN1

GeneCards

DCTN1

PRO

Q14203

Pharos - Targets

Q14203

Orphanet

DCTN1

GlyGen

Q14203

PDB

2HKN, 2HL3, 1TXQ, 2HKQ, 2COY, 2HL5, 2HQH, 3TQ7, 3E2U

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.9	9
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.779	9
UniProt:P30622-1 CLIP1			0.76	7
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.725	6
UniProt:Q9NZ32 ACTR10	4	ACTR10 [cytosol] (R-HSA-6801556) ACTR10 [azurophil granule lumen] (R-HSA-6801080) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072)	0.712	7
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.712	7
UniProt:O75935 DCTN3	1	DCTN3 [cytosol] (R-HSA-380264)	0.712	7
UniProt:O00399 DCTN6	1	DCTN6 [cytosol] (R-HSA-2029035)	0.712	8
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.712	7
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.704	9
UniProt:P42025 ACTR1B	4	ACTR1B [cytosol] (R-HSA-2228745) ACTR1B [secretory granule lumen] (R-HSA-6801082) ACTR1B [extracellular region] (R-HSA-6806503) ACTR1B [ficolin-1-rich granule lumen] (R-HSA-6801063)	0.65	6
UniProt:P54256 HAP1			0.646	4
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.638	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.635	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	10
UniProt:P47755 CAPZA2	2	CAPZA2 [cytosol] (R-HSA-879448) CAPZA2(265-276) [extracellular region] (R-HSA-879417)	0.615	6
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.615	3
UniProt:P30622 CLIP1	3	CLIP1 [cytosol] (R-HSA-377732) CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane] (R-HSA-9842572) CLIP1(1-1083)-p-6Y LTK(488-864) fusion [plasma membrane] (R-HSA-9842573)	0.595	3
UniProt:O08788	1	Dctn1 [cytosol] (R-MMU-380301)	0.564	2
UniProt:Q99KJ8	1	Dctn2 [cytosol] (R-MMU-380302)	0.564	2
UniProt:Q9Z0Y1	1	Dctn3 [cytosol] (R-MMU-380264)	0.564	2
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q9UNH7 SNX6			0.499	2
UniProt:Q9BTE1 DCTN5	1	DCTN5 [cytosol] (R-HSA-2029012)	0.483	5
UniProt:Q13409 DYNC1I2	1	DYNC1I2 [cytosol] (R-HSA-201607)	0.483	2
UniProt:O75122 CLASP2	1	CLASP2 [cytosol] (R-HSA-376252)	0.483	2
UniProt:Q7Z460 CLASP1	1	CLASP1 [cytosol] (R-HSA-376230)	0.483	3
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.48	2
UniProt:Q6DN90 IQEC1			0.471	2
UniProt:Q9JK25	1	Clip1 [cytosol] (R-RNO-377732)	0.463	2
UniProt:Q8TCX1 DYNC2LI1	2	DYNC2LI1 [ciliary tip] (R-HSA-5625333) DYNC2LI1 [cilium] (R-HSA-5624862)	0.462	2