Reactome | ZW10 [cytosol]

ZW10 [cytosol]

Stable Identifier

R-CFA-377880

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

ZW10, A0A8I3RP75

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - Mitotic Spindle Checkpoint (Canis familiaris)
    - Amplification of signal from the kinetochores (Canis familiaris)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Canis familiaris)
        
        MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Mad1 binds kinetochore (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Release of activated MAD2 from kinetochores (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
- Cell Cycle, Mitotic (Canis familiaris)
  - M Phase (Canis familiaris)
    - Mitotic Metaphase and Anaphase (Canis familiaris)
      - Mitotic Anaphase (Canis familiaris)
        
        Separation of Sister Chromatids (Canis familiaris)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Separation of sister chromatids (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
    - Mitotic Prometaphase (Canis familiaris)
      - EML4 and NUDC in mitotic spindle formation (Canis familiaris)
        
        EML4 recruits NUDC to mitotic spindle (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
      - Kinetochore capture of astral microtubules (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
      - Resolution of Sister Chromatid Cohesion (Canis familiaris)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Kinetochore assembly (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        RZZ complex [cytosol] (Canis familiaris)
        
        ZW10 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RP75

Gene Names

ZW10

Reference Genes

BioGPS Gene:479433 ZW10

ENSEMBL:ENSCAFG00845000507.1

KEGG:cfa:479433 ZW10

Monarch:479433 ZW10

NCBI Gene:479433 ZW10

UCSC:A0A8I3RP75 ZW10

Reference Transcript

Other Identifiers

479433

Cfa.9032.1.A1_at

CfaAffx.21190.1.S1_s_at

GO:0000070

GO:0000132

GO:0000278

GO:0000775

GO:0000776

GO:0000922

GO:0005634

GO:0005694

GO:0005737

GO:0005783

GO:0005789

GO:0005811

GO:0005819

GO:0005828

GO:0005829

GO:0005856

GO:0006888

GO:0007010

GO:0007030

GO:0007080

GO:0007094

GO:0007096

GO:0015031

GO:0016020

GO:0016192

GO:0034501

GO:0043226

GO:0051301

GO:0065003

GO:0070939

GO:1990423

Participates

as a component of

Inferred From

ZW10 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_536569.4, XP_038392057.1, XP_038520781.1

ENSEMBL

ENSCAFP00845000649, ENSCAFG00845000507, ENSCAFT00845000860

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