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Regulation of HSF1-mediated heat shock response
Stable Identifier
R-HSA-3371453
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
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The ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomeric to trimeric state.
Literature References
PubMed ID
Title
Journal
Year
7623826
Multiple layers of regulation of human heat shock transcription factor 1
Rungger, D
,
Voellmy, R
,
Zuo, J
Mol. Cell. Biol.
1995
Participants
Events
Constitutive phosphorylation by pERK1/2
(Homo sapiens)
Constitutive phosphorylation by GSK3
(Homo sapiens)
p-S303,307-HSF1 binds YWHAE (14-3-3)
(Homo sapiens)
MAPKAPK2 phosphorylates HSF1
(Homo sapiens)
RPA1 binds HSF1
(Homo sapiens)
DBC1 is phosphorylated by ATM/ART
(Homo sapiens)
DBC1 binds SIRT1
(Homo sapiens)
SIRT1 binds to HSF1
(Homo sapiens)
SIRT1 deacetylates HSF1
(Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol
(Homo sapiens)
HSP110s exchange ATP for ADP on HSP70s:ADP
(Homo sapiens)
Hikeshi binds HSP70s:ATP
(Homo sapiens)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
(Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm
(Homo sapiens)
Participates
as an event of
Cellular response to heat stress (Homo sapiens)
Event Information
Go Biological Process
regulation of cellular response to heat (1900034)
Orthologous Events
Regulation of HSF1-mediated heat shock response (Bos taurus)
Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
Regulation of HSF1-mediated heat shock response (Canis familiaris)
Regulation of HSF1-mediated heat shock response (Danio rerio)
Regulation of HSF1-mediated heat shock response (Dictyostelium discoideum)
Regulation of HSF1-mediated heat shock response (Drosophila melanogaster)
Regulation of HSF1-mediated heat shock response (Gallus gallus)
Regulation of HSF1-mediated heat shock response (Mus musculus)
Regulation of HSF1-mediated heat shock response (Plasmodium falciparum)
Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
Regulation of HSF1-mediated heat shock response (Saccharomyces cerevisiae)
Regulation of HSF1-mediated heat shock response (Schizosaccharomyces pombe)
Regulation of HSF1-mediated heat shock response (Sus scrofa)
Regulation of HSF1-mediated heat shock response (Xenopus tropicalis)
Authored
Shamovsky, V (2013-10-29)
Reviewed
Pani, B (2014-02-17)
Created
Shamovsky, V (2013-05-13)
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