Reactome | SIRT1 deacetylates HSF1

SIRT1 deacetylates HSF1

Stable Identifier

R-HSA-3371467

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Sirtuin 1 (SIRT1) functions as a NAD(+)-dependent deacetylase, which regulates the heat shock response through deacetylation of HSF1 at Lys80. The acetylation at Lys80, which is located within DNA binding domain of HSF1 disrupts HSF1 DNA-binding ability. SIRT1-mediated stress-inducible regulation of HSF1 results in prolonged HSF1 binding to the heat shock promoter of hsp70 gene. The mechanism of the enzymatic reaction which couples NAD(+) hydrolysis with lysine deacetylation in the presence of acetylated peptide is described by several groups (Landry J et al. 2000; Sauve AA et al. 2001)

Literature References

PubMed ID	Title	Journal	Year
19914676	Substrate specificity of SIRT1-catalyzed lysine Nepsilon-deacetylation reaction probed with the side chain modified Nepsilon-acetyl-lysine analogs Jamonnak, N, Hirsch, BM, Pang, Y, Zheng, W	Bioorg. Chem.	2010
11747420	Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions Sauve, AA, Celic, I, Avalos, J, Deng, H, Boeke, JD, Schramm, VL	Biochemistry	2001
23349863	The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response Raynes, R, Pombier, KM, Nguyen, K, Brunquell, J, Mendez, JE, Westerheide, SD	PLoS ONE	2013
19229036	Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1 Westerheide, SD, Anckar, J, Stevens, SM, Sistonen, L, Morimoto, RI	Science	2009