Reactome | p-S303,307-HSF1 binds YWHAE (14-3-3)

p-S303,307-HSF1 binds YWHAE (14-3-3)

Stable Identifier

R-HSA-4793925

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

YWHAE (14-3-3epsilon) was found to bind directly to HSF1 and that binding required serine phosphorylation at Ser303 and Ser307 and, moreover, the strongest binding was detected when both residues were phosphorylated.

Literature References

PubMed ID	Title	Journal	Year
15364926	Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress Grammatikakis, N, Wang, X, Stevenson, MA, Calderwood, SK, Siganou, A	J. Biol. Chem.	2004
12917326	Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1 Grammatikakis, N, Wang, X, Calderwood, SK, Siganou, A	Mol. Cell. Biol.	2003