MAPKAPK2 phosphorylates HSF1

Stable Identifier
R-HSA-4793911
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylation on Ser-121 inhibits transactivation and promotes HSP90 binding

Literature References
PubMed ID Title Journal Year
16278218 Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding

Wang, X, Khaleque, MA, Zhao, MJ, Zhong, R, Gaestel, M, Calderwood, SK

J. Biol. Chem. 2006
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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of MAPKAPK2 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created