Reactome | SIRT1 binds to HSF1

SIRT1 binds to HSF1

Stable Identifier

R-HSA-3371518

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Surtuin 1 (SIRT1) has been shown to bind HSF1 and to function as a regulator of HSF1 DNA binding activity by controling the acetylation status of HSF1 (Westerheide SD et al 2009). SIRT1 mediates NAD(+)-dependent protein deacetylation.

Literature References

PubMed ID	Title	Journal	Year
23349863	The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response Mendez, JE, Brunquell, J, Nguyen, K, Westerheide, SD, Raynes, R, Pombier, KM	PLoS ONE	2013
19229036	Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1 Sistonen, L, Morimoto, RI, Westerheide, SD, Anckar, J, Stevens, SM	Science	2009