Reactome | SIRT1 binds to HSF1

SIRT1 binds to HSF1

Stable Identifier

R-HSA-3371518

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Surtuin 1 (SIRT1) has been shown to bind HSF1 and to function as a regulator of HSF1 DNA binding activity by controling the acetylation status of HSF1 (Westerheide SD et al 2009). SIRT1 mediates NAD(+)-dependent protein deacetylation.

Literature References

PubMed ID	Title	Journal	Year
23349863	The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response Raynes, R, Pombier, KM, Nguyen, K, Brunquell, J, Mendez, JE, Westerheide, SD	PLoS ONE	2013
19229036	Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1 Westerheide, SD, Anckar, J, Stevens, SM, Sistonen, L, Morimoto, RI	Science	2009