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Hikeshi binds HSP70s:ATP
Stable Identifier
R-HSA-5251942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Hikeshi (C11orf73) binds ATP-bound heat-shock 70 proteins in the cytosol - leave here
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
Hikeshi binds HSP70s:ATP (Homo sapiens)
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Protein Hikeshi (C11orf73) is a nuclear import carrier protein for heat-shock 70 proteins (HSP70s) in response to heat-shock stress. C11orf73 binds HSP70s in the cytosol, ready for nuclear import (Kose et al. 2012).
Literature References
PubMed ID
Title
Journal
Year
22541429
Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage
Imamoto, N
,
Furuta, M
,
Kose, S
Cell
2012
Participants
Input
Hikeshi [cytosol]
(Homo sapiens)
HSP70s:ATP [cytosol]
(Homo sapiens)
Output
Hikeshi:HSP70s:ATP [cytosol]
(Homo sapiens)
Participates
as an event of
Regulation of HSF1-mediated heat shock response (Homo sapiens)
Orthologous Events
Hikeshi binds HSP70s:ATP (Bos taurus)
Hikeshi binds HSP70s:ATP (Caenorhabditis elegans)
Hikeshi binds HSP70s:ATP (Canis familiaris)
Hikeshi binds HSP70s:ATP (Danio rerio)
Hikeshi binds HSP70s:ATP (Dictyostelium discoideum)
Hikeshi binds HSP70s:ATP (Mus musculus)
Hikeshi binds HSP70s:ATP (Rattus norvegicus)
Hikeshi binds HSP70s:ATP (Saccharomyces cerevisiae)
Hikeshi binds HSP70s:ATP (Schizosaccharomyces pombe)
Hikeshi binds HSP70s:ATP (Sus scrofa)
Hikeshi binds HSP70s:ATP (Xenopus tropicalis)
Authored
Jassal, B (2014-02-05)
Reviewed
D'Eustachio, P (2015-02-11)
Created
Jassal, B (2014-02-05)
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