RPA1 binds HSF1

Stable Identifier
R-HSA-5333051
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RPA1 binds HSF1
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Replication protein A (RPA) is a heterotrimeric, single-strand DNA-binding protein required for DNA metabolism, including DNA replication, repair, and recombination. The physical interaction between the wing motif of human HSF1 and RPA1 was found to provide HSF1 access to nucleosomal DNA, which is important for both basal and inducible gene expression. This access lead to preloading of RNA polymerase II and opened the chromatin structure by recruiting a histone chaperone FACT (Fujimoto M et al. 2012).
Literature References
PubMed ID Title Journal Year
22940245 RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT

Fujimoto, M, Takaki, E, Takii, R, Tan, K, Prakasam, R, Hayashida, N, Iemura, S, Natsume, T, Nakai, A

Mol. Cell 2012
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Authored
Shamovsky, V  (2014-02-18)
Reviewed
Pani, B  (2014-02-17)
Created
Shamovsky, V  (2014-02-18)
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