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p-4Y-PIK3AP1 [plasma membrane]
Stable Identifier
R-HSA-984814
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BCAP phosphorylated at Tyr-263, Tyr-419, Tyr-444, and Tyr-459, Phosphoinositide 3-kinase adapter protein 1, PIK3AP1, BCAP_HUMAN, B cell adaptor for phosphoinositide 3-kinase
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6ZUJ8 PIK3AP1
Gene Names
PIK3AP1, BCAP
Chain
chain:1-805
Reference Genes
BioGPS Gene:118788 PIK3AP1
COSMIC (genes):PIK3AP1 PIK3AP1
CTD Gene:118788 PIK3AP1
dbSNP Gene:118788 PIK3AP1
ENSEMBL:ENSG00000155629 PIK3AP1
ENSEMBL_homo_sapiens_GENE:ENSG00000155629.15 PIK3AP1
HGNC:30034 PIK3AP1
KEGG Gene (Homo sapiens):118788 PIK3AP1
Monarch:118788 PIK3AP1
NCBI Gene:118788 PIK3AP1
OMIM:607942 PIK3AP1
UCSC:Q6ZUJ8 PIK3AP1
Reference Transcript
RefSeq:XM_005269498.1 PIK3AP1
RefSeq:XM_005269499.1 PIK3AP1
RefSeq:NM_152309.2 PIK3AP1
Other Identifiers
11719029_at
11748798_a_at
118788
1554508_PM_at
1554508_at
16717005
226459_PM_at
226459_at
3301915
3301916
3301917
3301918
3301919
3301922
3301925
3301926
3301927
3301931
3301940
3301942
3301943
3301947
3301948
3301949
3301954
3301956
3301957
3301958
3301959
3301961
3301962
3301964
3301988
3301992
43613_at
48664_at
52335_at
52337_g_at
7935337
A_23_P104445
A_33_P3879161
GE87149
GO:0002376
GO:0005102
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006954
GO:0007165
GO:0016020
GO:0023052
GO:0034134
GO:0034142
GO:0034154
GO:0034162
GO:0036312
GO:0042802
GO:0050727
GO:0051897
GO:0098542
HMNXSV003013635
Hs.86437.0.A1_3p_at
Hs2.374836.2.A1_3p_at
ILMN_1652787
PH_hs_0018166
TC10001559.hg
Participates
as an input of
p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
as a component of
BCAP Signalosome [plasma membrane] (Homo sapiens)
Inferred From
p-Y266,Y423,Y448,Y463-PIK3AP1 [plasma membrane]
(Gallus gallus)
Inferred To
phospho-Pik3ap1 [plasma membrane]
(Mus musculus)
phospho-Pik3ap1 [plasma membrane]
(Rattus norvegicus)
phospho-PIK3AP1 [plasma membrane]
(Bos taurus)
phospho-PIK3AP1 [plasma membrane]
(Canis familiaris)
phospho-PIK3AP1 [plasma membrane]
(Gallus gallus)
phospho-PIK3AP1 [plasma membrane]
(Sus scrofa)
phospho-stumps [plasma membrane]
(Drosophila melanogaster)
phospho-p-4Y-PIK3AP1 [plasma membrane]
(Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 263
Coordinate
263
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 419
Coordinate
419
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 444
Coordinate
444
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 459
Coordinate
459
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_689522.2
,
XP_005269555.1
,
XP_005269556.1
OpenTargets
ENSG00000155629
GeneCards
Q6ZUJ8
HPA
ENSG00000155629-PIK3AP1
Ensembl
ENST00000371110
,
ENSP00000339826
,
ENSG00000155629
,
ENST00000339364
,
ENST00000371109
,
ENSP00000360151
,
ENSP00000360150
PRO
Q6ZUJ8
Pharos - Targets
Q6ZUJ8
Orphanet
24812
PDB
6SWS
,
5FOR
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.738
5
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