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p-4Y-PIK3AP1 [plasma membrane]
Stable Identifier
R-HSA-984814
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BCAP phosphorylated at Tyr-263, Tyr-419, Tyr-444, and Tyr-459, Phosphoinositide 3-kinase adapter protein 1, PIK3AP1, BCAP_HUMAN, B cell adaptor for phosphoinositide 3-kinase
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BCAP Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
BCAP Signalosome [plasma membrane] (Homo sapiens)
p-4Y-PIK3AP1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6ZUJ8 PIK3AP1
Gene Names
PIK3AP1, BCAP
Chain
chain:1-805
Reference Genes
BioGPS Gene:118788 PIK3AP1
COSMIC (genes):PIK3AP1 PIK3AP1
CTD Gene:118788 PIK3AP1
dbSNP Gene:118788 PIK3AP1
ENSEMBL:ENSG00000155629 PIK3AP1
HGNC:30034 PIK3AP1
KEGG:hsa:118788 PIK3AP1
Monarch:118788 PIK3AP1
NCBI Gene:118788 PIK3AP1
OMIM:607942 PIK3AP1
UCSC:Q6ZUJ8 PIK3AP1
Reference Transcript
RefSeq:XM_005269499.1 PIK3AP1
RefSeq:NM_152309.2 PIK3AP1
RefSeq:XM_005269498.1 PIK3AP1
Participates
as an input of
p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
as a component of
BCAP Signalosome [plasma membrane] (Homo sapiens)
Inferred From
p-Y266,Y423,Y448,Y463-PIK3AP1 [plasma membrane]
(Gallus gallus)
Inferred To
phospho-Pik3ap1 [plasma membrane]
(Mus musculus)
phospho-Pik3ap1 [plasma membrane]
(Rattus norvegicus)
phospho-PIK3AP1 [plasma membrane]
(Bos taurus)
phospho-PIK3AP1 [plasma membrane]
(Canis familiaris)
phospho-PIK3AP1 [plasma membrane]
(Gallus gallus)
phospho-PIK3AP1 [plasma membrane]
(Sus scrofa)
phospho-stumps [plasma membrane]
(Drosophila melanogaster)
phospho-pik3ap1 [plasma membrane]
(Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 263
Coordinate
263
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 419
Coordinate
419
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 444
Coordinate
444
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 459
Coordinate
459
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_689522.2
,
XP_005269555.1
,
XP_005269556.1
ENSEMBL
ENSP00000339826
,
ENSG00000155629
,
ENST00000371109
,
ENSP00000360150
,
ENSP00000360151
,
ENST00000371110
,
ENST00000339364
OpenTargets
ENSG00000155629
GeneCards
PIK3AP1
HPA
ENSG00000155629-PIK3AP1
PRO
Q6ZUJ8
Pharos - Targets
Q6ZUJ8
PDB
5FOR
,
6SWS
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.798
6
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.527
3
UniProt:O00755 WNT7A
9
WNT7A [extracellular region]
(R-HSA-517404)
N4GlycoAsn-PalmS WNT7A [extracellular exosome]
(R-HSA-3781951)
N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane]
(R-HSA-3781961)
WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238312)
N4GlycoAsn-WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238249)
N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen]
(R-HSA-3238354)
N4GlycoAsn-PalmS WNT7A [Golgi lumen]
(R-HSA-3247778)
N4GlycoAsn-PalmS WNT7A [extracellular region]
(R-HSA-3247774)
N4GlycoAsn-PalmS WNT7A [plasma membrane]
(R-HSA-3247833)
0.527
2
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