Reactome | WLS [extracellular exosome]

WLS [extracellular exosome]

Stable Identifier

R-HSA-3781960

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular exosome

Synonyms

GPR177, EVI

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External Reference Information

External Reference

UniProt:Q5T9L3 WLS

Gene Names

WLS, C1orf139, GPR177, UNQ85/PRO18667

Chain

chain:1-541

Reference Genes

COSMIC (genes):WLS WLS

dbSNP Gene:79971 WLS

ENSEMBL:ENSG00000116729 WLS

Participates

as a component of

WLS:WNT [extracellular exosome] (Homo sapiens)

Other forms of this molecule

WLS [endocytic vesicle membrane]

WLS [early endosome membrane]

WLS [Golgi membrane]

WLS [plasma membrane]

Inferred To

mig-14 [extracellular exosome] (Caenorhabditis elegans)

Wls [extracellular exosome] (Mus musculus)

Wls [extracellular exosome] (Rattus norvegicus)

wls [extracellular exosome] (Drosophila melanogaster)

wls [extracellular exosome] (Xenopus tropicalis)

WLS [extracellular exosome] (Bos taurus)

WLS [extracellular exosome] (Canis familiaris)

WLS [extracellular exosome] (Gallus gallus)

WLS [extracellular exosome] (Sus scrofa)

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.819	11
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.784	6
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.564	3
UniProt:P41221 WNT5A	10	N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (R-HSA-3247777) N4GlycoAsn-PalmS WNT5A(36-380) [plasma membrane] (R-HSA-3247799) N4GlycoAsn-PalmS WNT5A(36-380) [Golgi lumen] (R-HSA-3247788) N4GlycoAsn-PalmS WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238371) N4GlycoAsn-WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238239) WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238300) N4GlycoAsn-PalmS WNT5A(36-380) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138454) N4GlycoAsn-PalmS WNT5A(36-380) [extracellular exosome] (R-HSA-3781973) N4GlycoAsn-PalmS WNT5A(36-380) [endocytic vesicle membrane] (R-HSA-3781982) WNT5A [extracellular region] (R-HSA-517396)	0.564	3
UniProt:P56705 WNT4	9	WNT4 [extracellular region] (R-HSA-517385) N4GlycoAsn-PalmS WNT4 [extracellular exosome] (R-HSA-3781964) N4GlycoAsn-PalmS WNT4 [endocytic vesicle membrane] (R-HSA-3781978) WNT4 [endoplasmic reticulum lumen] (R-HSA-3238297) N4GlycoAsn-WNT4 [endoplasmic reticulum lumen] (R-HSA-3238235) N4GlycoAsn-PalmS WNT4 [endoplasmic reticulum lumen] (R-HSA-3238347) N4GlycoAsn-PalmS WNT4 [Golgi lumen] (R-HSA-3247779) N4GlycoAsn-PalmS WNT4 [extracellular region] (R-HSA-3247794) N4GlycoAsn-PalmS WNT4 [plasma membrane] (R-HSA-3247809)	0.527	3
UniProt:P43681 CHRNA4	1	CHRNA4 [plasma membrane] (R-HSA-507836)	0.527	2
UniProt:Q8IVM8 S22A9			0.527	2
UniProt:P11230 ACHB			0.527	2
UniProt:Q1HG44 DUOXA2	1	DUOXA2 [plasma membrane] (R-HSA-9961463)	0.527	2
UniProt:Q01959 SLC6A3	5	SLC6A3 [plasma membrane] (R-HSA-379482) SLC6A3 L368Q [plasma membrane] (R-HSA-5660710) SLC6A3 L224P [plasma membrane] (R-HSA-5660718) SLC6A3 P395L [plasma membrane] (R-HSA-5660716) SLC6A3 R521W [plasma membrane] (R-HSA-5660729)	0.524	2