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WLS [early endosome membrane]
Stable Identifier
R-HSA-3247745
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
GPR177, EVI
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
WNT ligand biogenesis and trafficking (Homo sapiens)
Retromer associates with WLS (Homo sapiens)
WLS [early endosome membrane] (Homo sapiens)
WLS:retromer [early endosome membrane] (Homo sapiens)
WLS [early endosome membrane] (Homo sapiens)
Retromer recycles WLS to the Golgi (Homo sapiens)
WLS:retromer [early endosome membrane] (Homo sapiens)
WLS [early endosome membrane] (Homo sapiens)
WLS is endocytosed to the early endosome (Homo sapiens)
WLS [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5T9L3 WLS
Gene Names
WLS, C1orf139, GPR177, UNQ85/PRO18667
Chain
chain:1-541
Reference Genes
BioGPS Gene:79971 WLS
COSMIC (genes):WLS WLS
CTD Gene:79971 WLS
dbSNP Gene:79971 WLS
ENSEMBL:ENSG00000116729 WLS
ENSEMBL:ENSG00000116729.14 WLS
HGNC:30238 WLS
KEGG Gene (Homo sapiens):79971 WLS
Monarch:79971 WLS
NCBI Gene:79971 WLS
OMIM:611514 WLS
UCSC:Q5T9L3 WLS
Reference Transcript
RefSeq:NM_001002292.3 WLS
RefSeq:NM_001193334.1 WLS
RefSeq:NM_024911.6 WLS
Other Identifiers
11718760_a_at
11718761_a_at
11733513_a_at
11745018_a_at
16688339
221958_PM_s_at
221958_s_at
228949_PM_at
228949_at
228950_PM_s_at
228950_s_at
2417391
2417392
2417400
2417401
2417402
2417418
2417421
2417422
2417423
2417427
2417429
2417433
2417434
2417435
2417436
2417437
2417446
2417447
2417456
2417457
2417458
7916862
79971
87701_at
A_24_P256380
A_33_P3280721
GE87389
GO:0000139
GO:0001707
GO:0005515
GO:0005576
GO:0005615
GO:0005768
GO:0005769
GO:0005783
GO:0005789
GO:0005794
GO:0005802
GO:0005829
GO:0005886
GO:0006886
GO:0009948
GO:0012505
GO:0016020
GO:0016055
GO:0017147
GO:0023052
GO:0030177
GO:0030659
GO:0030666
GO:0030901
GO:0030902
GO:0031017
GO:0031410
GO:0031901
GO:0042802
GO:0043123
GO:0043226
GO:0048856
GO:0061355
GO:0061357
GO:0070062
GO:0071529
GO:0090263
HMNXSV003052717
Hs.250746.1.S1_3p_a_at
Hs.250746.1.S1_3p_at
Hs.250746.2.S1_3p_a_at
ILMN_1660549
ILMN_1671260
ILMN_1753913
ILMN_2283325
ILMN_2399769
PH_hs_0023577
TC01002763.hg
Participates
as an input of
Retromer associates with WLS (Homo sapiens)
as a component of
WLS:retromer [early endosome membrane] (Homo sapiens)
as an output of
WLS is endocytosed to the early endosome (Homo sapiens)
Other forms of this molecule
WLS [extracellular exosome]
WLS [endocytic vesicle membrane]
WLS [Golgi membrane]
WLS [plasma membrane]
Inferred To
mig-14 [early endosome membrane]
(Caenorhabditis elegans)
WLS [early endosome membrane]
(Bos taurus)
WLS [early endosome membrane]
(Canis familiaris)
WLS [early endosome membrane]
(Gallus gallus)
WLS [early endosome membrane]
(Sus scrofa)
wls [early endosome membrane]
(Drosophila melanogaster)
wls [early endosome membrane]
(Xenopus tropicalis)
gpr117 [early endosome membrane]
(Danio rerio)
Ghost homologue of WLS [early endosome membrane]
(Dictyostelium discoideum)
Ghost homologue of WLS [early endosome membrane]
(Saccharomyces cerevisiae)
Ghost homologue of WLS [early endosome membrane]
(Schizosaccharomyces pombe)
Wls [early endosome membrane]
(Mus musculus)
Wls [early endosome membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_079187.3
,
NP_001180263.1
,
NP_001002292.3
OpenTargets
ENSG00000116729
HPA
ENSG00000116729-WLS
GeneCards
Q5T9L3
Ensembl
ENSG00000116729
,
ENSP00000262348
,
ENSP00000360015
,
ENST00000262348
,
ENSP00000346829
,
ENST00000370976
,
ENST00000354777
PRO
Q5T9L3
Pharos - Targets
Q5T9L3
PDB
7DRT
,
7KC4
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35372 OPRM1
1
OPRM1 [plasma membrane]
(R-HSA-60951)
0.819
11
UniProt:P56704 WNT3A
10
WNT3A [extracellular region]
(R-HSA-201710)
N4GlycoAsn-PalmS WNT3A [extracellular exosome]
(R-HSA-3781968)
N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane]
(R-HSA-3781944)
N4GlycoAsn-PalmS WNT3A [early endosome membrane]
(R-HSA-5368483)
WNT3A [endoplasmic reticulum lumen]
(R-HSA-3238292)
N4GlycoAsn-WNT3A [endoplasmic reticulum lumen]
(R-HSA-3238231)
N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen]
(R-HSA-3238344)
N4GlycoAsn-PalmS WNT3A [Golgi lumen]
(R-HSA-3247832)
N4GlycoAsn-PalmS WNT3A [extracellular region]
(R-HSA-3247784)
N4GlycoAsn-PalmS WNT3A [plasma membrane]
(R-HSA-3247807)
0.635
4
UniProt:Q01959 SLC6A3
5
SLC6A3 [plasma membrane]
(R-HSA-379482)
SLC6A3 L368Q [plasma membrane]
(R-HSA-5660710)
SLC6A3 L224P [plasma membrane]
(R-HSA-5660718)
SLC6A3 P395L [plasma membrane]
(R-HSA-5660716)
SLC6A3 R521W [plasma membrane]
(R-HSA-5660729)
0.524
2
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