Reactome | WLS [endocytic vesicle membrane]

WLS [endocytic vesicle membrane]

Stable Identifier

R-HSA-3781954

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle membrane

Synonyms

GPR177, EVI

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q5T9L3 WLS

Gene Names

WLS, C1orf139, GPR177, UNQ85/PRO18667

Chain

chain:1-541

Reference Genes

BioGPS Gene:79971 WLS

COSMIC (genes):WLS WLS

CTD Gene:79971 WLS

dbSNP Gene:79971 WLS

ENSEMBL:ENSG00000116729 WLS

HGNC:30238 WLS

KEGG:hsa:79971 WLS

Monarch:79971 WLS

NCBI Gene:79971 WLS

OMIM:611514 WLS

UCSC:Q5T9L3 WLS

Reference Transcript

Participates

as a component of

WLS:WNT [multivesicular body, internal vesicle] (Homo sapiens)

Other forms of this molecule

WLS [extracellular exosome]

WLS [early endosome membrane]

WLS [Golgi membrane]

WLS [plasma membrane]

Inferred To

mig-14 [endocytic vesicle membrane] (Caenorhabditis elegans)

Wls [endocytic vesicle membrane] (Mus musculus)

Wls [endocytic vesicle membrane] (Rattus norvegicus)

WLS [endocytic vesicle membrane] (Bos taurus)

WLS [endocytic vesicle membrane] (Canis familiaris)

WLS [endocytic vesicle membrane] (Gallus gallus)

WLS [endocytic vesicle membrane] (Sus scrofa)

wls [endocytic vesicle membrane] (Drosophila melanogaster)

wls [endocytic vesicle membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001180263.1, NP_079187.3, NP_001002292.3

ENSEMBL

ENST00000370976, ENSG00000116729, ENST00000262348, ENSP00000262348, ENST00000354777, ENSP00000360015, ENSP00000346829

OpenTargets

ENSG00000116729

GeneCards

WLS

HPA

ENSG00000116729-WLS

PRO

Q5T9L3

Pharos - Targets

Q5T9L3

PDB

8TZS, 8TZP, 8TZR, 8TZO, 7DRT, 7KC4

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.819	11
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.721	5
UniProt:P41221 WNT5A	10	N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (R-HSA-3247777) N4GlycoAsn-PalmS WNT5A(36-380) [plasma membrane] (R-HSA-3247799) N4GlycoAsn-PalmS WNT5A(36-380) [Golgi lumen] (R-HSA-3247788) N4GlycoAsn-PalmS WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238371) N4GlycoAsn-WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238239) WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238300) N4GlycoAsn-PalmS WNT5A(36-380) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138454) N4GlycoAsn-PalmS WNT5A(36-380) [extracellular exosome] (R-HSA-3781973) N4GlycoAsn-PalmS WNT5A(36-380) [endocytic vesicle membrane] (R-HSA-3781982) WNT5A [extracellular region] (R-HSA-517396)	0.564	3
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.564	3
UniProt:Q01959 SLC6A3	5	SLC6A3 [plasma membrane] (R-HSA-379482) SLC6A3 L368Q [plasma membrane] (R-HSA-5660710) SLC6A3 L224P [plasma membrane] (R-HSA-5660718) SLC6A3 P395L [plasma membrane] (R-HSA-5660716) SLC6A3 R521W [plasma membrane] (R-HSA-5660729)	0.524	2