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PTK6 binds ARAP1
Stable Identifier
R-HSA-8848864
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Homo sapiens)
PTK6 binds ARAP1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated PTK6 (BRK) binds GTPase activating protein ARAP1. This interaction involves the SH2 domain of PTK6 (Kang et al. 2010).
Literature References
PubMed ID
Title
Journal
Year
20554524
PTK6 inhibits down-regulation of EGF receptor through phosphorylation of ARAP1
Randazzo, PA
,
Lee, ES
,
Lee, ST
,
Yoon, HY
,
Kang, SA
J. Biol. Chem.
2010
Participants
Input
ARAP1 [cytosol]
(Homo sapiens)
p-Y342-PTK6 [cytosol]
(Homo sapiens)
Output
p-Y342-PTK6:ARAP1 [cytosol]
(Homo sapiens)
Participates
as an event of
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Homo sapiens)
Orthologous Events
PTK6 binds ARAP1 (Bos taurus)
PTK6 binds ARAP1 (Caenorhabditis elegans)
PTK6 binds ARAP1 (Mus musculus)
PTK6 binds ARAP1 (Rattus norvegicus)
PTK6 binds ARAP1 (Sus scrofa)
Authored
Orlic-Milacic, M (2016-01-05)
Reviewed
Pires, IM (2016-02-07)
Created
Orlic-Milacic, M (2015-12-11)
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