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THBD [plasma membrane]
Stable Identifier
R-HSA-141030
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
thrombomodulin
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)
activated thrombin:thrombomodulin [plasma membrane] (Homo sapiens)
THBD [plasma membrane] (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C (Homo sapiens)
activated thrombin:thrombomodulin [plasma membrane] (Homo sapiens)
THBD [plasma membrane] (Homo sapiens)
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)
THBD [plasma membrane] (Homo sapiens)
activated thrombin:thrombomodulin [plasma membrane] (Homo sapiens)
THBD [plasma membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
2822087
Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene
Sadler, JE
,
Majerus, PW
,
Dittman, WA
,
Wen, DZ
,
Deaven, LL
,
Ye, RD
Biochemistry
1987
External Reference Information
External Reference
UniProt:P07204 THBD
Gene Names
THBD, THRM
Chain
signal peptide:1-18, chain:19-575
Reference Genes
BioGPS Gene:7056 THBD
COSMIC (genes):THBD THBD
CTD Gene:7056 THBD
dbSNP Gene:7056 THBD
ENSEMBL:ENSG00000178726 THBD
HGNC:11784 THBD
KEGG:hsa:7056 THBD
Monarch:7056 THBD
NCBI Gene:7056 THBD
OMIM:188040 THBD
UCSC:P07204 THBD
Reference Transcript
RefSeq:NM_000361.2 THBD
Other Identifiers
11719673_a_at
11755219_a_at
16917849
203887_PM_s_at
203887_s_at
203888_PM_at
203888_at
237252_PM_at
237252_at
33803_at
3901043
3901044
3901045
3901046
3901047
3901048
3901049
3901050
3901051
3901052
3901053
3901054
47860_at
7056
8065353
A_23_P91390
GE57470
GO:0004888
GO:0005509
GO:0005515
GO:0005615
GO:0005774
GO:0005886
GO:0006508
GO:0007565
GO:0007596
GO:0009897
GO:0009986
GO:0010165
GO:0010544
GO:0016020
GO:0016327
GO:0022414
GO:0030195
GO:0031638
GO:0032496
GO:0038023
GO:0051591
GO:0051604
GO:0051918
GO:0060089
GO:0072377
GO:1905370
HMNXSV003058355
Hs.72092.0.S1_3p_at
ILMN_1759787
J02973_rna1_at
PH_hs_0027537
TC20000702.hg
g4507482_3p_a_at
Participates
as an input of
activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin (Homo sapiens)
as a component of
activated thrombin:thrombomodulin [plasma membrane] (Homo sapiens)
Inferred To
Thbd [plasma membrane]
(Mus musculus)
Thbd [plasma membrane]
(Rattus norvegicus)
THBD [plasma membrane]
(Bos taurus)
THBD [plasma membrane]
(Canis familiaris)
THBD [plasma membrane]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000178726
ENSEMBL
ENST00000377103
,
ENSP00000366307
HPA
ENSG00000178726-THBD
PRO
P07204
Pharos - Targets
P07204
Orphanet
THBD
PDB
3GIS
,
1ZAQ
,
1HLT
,
7T4R
,
1DX5
,
1FGE
,
1FGD
,
1TMR
,
5TO3
,
1DQB
,
1ADX
,
1EGT
,
2ADX
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q8N4V1 MMGT1
1
MMGT1 [Golgi membrane]
(R-HSA-5216137)
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q9NQQ7-3 Q9NQQ73
0.556
3
UniProt:Q9Y320 TMX2
0.556
3
IntAct:EBI-22589183 CCSB ORF ID
0.556
3
UniProt:Q9UPV7 PHF24
0.556
3
UniProt:P55056 APOC4
1
APOC4 [extracellular region]
(R-HSA-5215930)
0.556
3
UniProt:Q9NUH8 TM14B
0.556
3
UniProt:Q9NVV5-2 AIG1
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:Q9UHD4 CIDEB
0.556
3
UniProt:Q5JX71 F209A
0.556
3
UniProt:Q6NTF9-3 Q6NTF93
0.556
3
UniProt:Q53FP2 NACHO
0.556
3
UniProt:Q9BZV2 SLC19A3
1
SLC19A3 [plasma membrane]
(R-HSA-199643)
0.556
3
UniProt:P15941-11 MUC1
0.556
3
UniProt:P11912 CD79A
2
p-Y188,Y199-CD79A [plasma membrane]
(R-HSA-983539)
CD79A [plasma membrane]
(R-HSA-197154)
0.556
3
UniProt:Q8TED1 GPX8
1
GPX8 [endoplasmic reticulum lumen]
(R-HSA-3341303)
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:P43628 KIR2DL3
1
KIR2DL3 [plasma membrane]
(R-HSA-3006532)
0.556
3
UniProt:Q9BQA9 CYBC1
0.556
3
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