Reactome | IGF2(25-91) [extracellular region]

IGF2(25-91) [extracellular region]

Stable Identifier

R-HSA-2404175

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

IGF2, Insulin-like growth factor II, IGF2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P22692 IGFBP4

Expand all

External Reference Information

External Reference

UniProt:P01344 IGF2

Gene Names

IGF2, IGF-2, PP1446

Chain

signal peptide:1-24, chain:25-91, chain:26-91, propeptide:92-180, peptide:93-126

Reference Genes

BioGPS Gene:3481 IGF2

COSMIC - genes:IGF2 IGF2

CTD Gene:3481 IGF2

dbSNP Gene:3481 IGF2

ENSEMBL:ENSG00000167244 IGF2

HGNC:5466 IGF2

KEGG:hsa:3481 IGF2

Monarch:3481 IGF2

NCBI Gene:3481 IGF2

OMIM:147470 IGF2

UCSC:P01344 IGF2

Reference Transcript

Other Identifiers

11739786_s_at

11739787_a_at

11742637_s_at

11753726_s_at

11756003_x_at

11758400_s_at

1591_s_at

1664_at

202409_PM_at

202409_at

202410_PM_x_at

202410_x_at

2079_s_at

210881_PM_s_at

210881_s_at

3359120

3359122

3359123

3359124

3359125

3359127

3359129

3359131

3359133

3359135

3359136

3359137

3359138

3359139

3359140

3359141

3359142

3359143

3359144

3359148

3359150

3359152

3359154

3359156

3359160

3359166

3359168

3359170

3481

36782_s_at

7945688

A_23_P421379

GE537008

GE79183

GE84332

GO:0000122

GO:0001503

GO:0001649

GO:0001701

GO:0001892

GO:0005158

GO:0005159

GO:0005178

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005975

GO:0006006

GO:0006325

GO:0006355

GO:0008083

GO:0008284

GO:0008286

GO:0009887

GO:0030154

GO:0030297

GO:0031017

GO:0031093

GO:0040018

GO:0042104

GO:0043410

GO:0043539

GO:0045725

GO:0045840

GO:0045944

GO:0046622

GO:0046628

GO:0048009

GO:0048018

GO:0048633

GO:0048856

GO:0051146

GO:0051147

GO:0051148

GO:0051781

GO:0051897

GO:0060669

GO:0071514

GO:0098772

GO:1905564

HMNXSV003007403

Hs.251664.0.A2_3p_at

ILMN_1699867

ILMN_2298035

ILMN_2328463

ILMN_2413956

J03242_s_at

M17863_s_at

PH_hs_0029812

PH_hs_0032172

PH_hs_0040332

TC11003001.hg

g182527_3p_a_at

Participates

as an output of

CHD8:CTCF-dependent repression of maternal IGF2 gene expression (Homo sapiens)

as a member of

IGF1,2 [extracellular region] (Homo sapiens)

Other forms of this molecule

IGF2(25-91) [platelet alpha granule lumen]

Inferred To

IGF2 [extracellular region] (Bos taurus)

IGF2 [extracellular region] (Canis familiaris)

IGF2 [extracellular region] (Gallus gallus)

IGF2 [extracellular region] (Sus scrofa)

Homologues of IGF2(25-91) [extracellular region] (Sus scrofa)

igf2 [extracellular region] (Xenopus tropicalis)

Igf2 [extracellular region] (Mus musculus)

Igf2 [extracellular region] (Rattus norvegicus)

igf2b [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_001121070.1, NP_001007140.2, NP_000603.1, NP_001278790.1, NP_001278791.1

ENSEMBL

ENST00000695541, ENST00000434045, ENSP00000414497, ENST00000381406, ENSP00000391826, ENST00000481781, ENSP00000511998, ENSP00000511997, ENST00000418738, ENST00000381389, ENSP00000370799, ENST00000381395, ENSP00000402047, ENST00000416167, ENSG00000167244, ENST00000381392, ENSP00000370813, ENSP00000370802, ENSP00000370796

OpenTargets

ENSG00000167244

HPA

ENSG00000167244-IGF2

GeneCards

IGF2

PRO

P01344

Pharos - Targets

P01344

GlyGen

P01344

Orphanet

IGF2

PDB

6VWI, 2V5P, 2L29, 3E4Z, 8YSZ, 6UM2, 5L3M, 5L3L, 5L3N, 6VWG, 3KR3, 8U4C, 8U4E, 8VJC, 1IGL, 8VJB

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.643	4
UniProt:P11717 IGF2R	7	IGF2R [secretory granule membrane] (R-HSA-6803320) IGF2R [plasma membrane] (R-HSA-6806532) IGF2R [clathrin-coated endocytic vesicle membrane] (R-HSA-8869091) IGF2R [trans-Golgi network membrane] (R-HSA-6814608) IGF2R [transport vesicle] (R-HSA-6814609) IGF2R [cytoplasmic vesicle membrane] (R-HSA-434213) IGF2R [Golgi membrane] (R-HSA-434345)	0.558	17
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.527	2
UniProt:P24593 IGFBP5	5	IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.527	3
UniProt:Q8IWV7 UBR1	1	UBR1 [cytosol] (R-HSA-976040)	0.527	3
UniProt:Q5XPI4 RNF123	2	K63polyUb-RNF123 [cytosol] (R-HSA-6783055) RNF123 [cytosol] (R-HSA-975996)	0.527	3
UniProt:Q8IWV8 UBR2	1	UBR2 [cytosol] (R-HSA-976055)	0.527	2
UniProt:P06213 INSR	6	INSR(28-758) [plasma membrane] (R-HSA-74668) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(763-1382) [plasma membrane] (R-HSA-74669) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719)	0.527	3
UniProt:O95749 GGPS1	1	GGPS1 [cytosol] (R-HSA-191415)	0.527	3
UniProt:Q9BSL1 UBAC1	1	UBAC1 [cytosol] (R-HSA-8851644)	0.527	3
UniProt:P22692 IGFBP4	5	IGFBP4 [extracellular region] (R-HSA-381421) IGFBP4(157-237) [extracellular region] (R-HSA-381510) IGFBP4(22-156) [extracellular region] (R-HSA-381516) IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8956754) p-IGFBP4 [endoplasmic reticulum lumen] (R-HSA-8957038)	0.483	3

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