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UBR2 [cytosol]
Stable Identifier
R-HSA-976055
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase UBR2, UBR2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBR2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IWV8 UBR2
Gene Names
UBR2, C6orf133, KIAA0349
Chain
initiator methionine:1, chain:2-1755
Reference Genes
BioGPS Gene:23304 Q8IWV82
COSMIC - genes:UBR2 UBR2
CTD Gene:23304 Q8IWV82
dbSNP Gene:23304 UBR2
ENSEMBL:ENSG00000024048 UBR2
HGNC:21289 Q8IWV82
KEGG:hsa:23304 Q8IWV82
Monarch:23304 Q8IWV82
NCBI Gene:23304 Q8IWV82
OMIM:609134 Q8IWV82
UCSC:Q8IWV8 Q8IWV82
Reference Transcript
RefSeq:NM_001363705.2 Q8IWV82
RefSeq:NM_001184801.2 Q8IWV82
RefSeq:NM_015255.3 Q8IWV82
Participates
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
ubr-1 [cytosol]
(Caenorhabditis elegans)
ubr1 [cytosol]
(Schizosaccharomyces pombe)
Ubr2 [cytosol]
(Rattus norvegicus)
UBR2 [cytosol]
(Bos taurus)
UBR2 [cytosol]
(Canis familiaris)
UBR2 [cytosol]
(Dictyostelium discoideum)
UBR2 [cytosol]
(Gallus gallus)
UBR2 [cytosol]
(Mus musculus)
UBR2 [cytosol]
(Saccharomyces cerevisiae)
UBR2 [cytosol]
(Sus scrofa)
Ubr1 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_056070.1
,
NP_001171730.1
,
NP_001350634.1
ENSEMBL
ENST00000372901
,
ENSP00000361994
,
ENST00000372903
,
ENSP00000361992
,
ENSP00000361990
,
ENST00000372899
,
ENSG00000024048
OpenTargets
ENSG00000024048
GeneCards
UBR2
HPA
ENSG00000024048-UBR2
PRO
Q8IWV8
Pharos - Targets
Q8IWV8
GlyGen
Q8IWV8
HMDB Protein
HMDBP09274
PDB
5TDB
,
9DNQ
,
5TDA
,
5UM3
,
9DNP
,
5TDD
,
9DNR
,
3NY3
,
3NY2
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.527
2
UniProt:P16383 GCFC2
1
GCFC2 [nucleoplasm]
(R-HSA-8869311)
0.527
2
UniProt:P01344 IGF2
2
IGF2(25-91) [platelet alpha granule lumen]
(R-HSA-3006322)
IGF2(25-91) [extracellular region]
(R-HSA-2404175)
0.527
2
UniProt:Q6IN84 MRM1
1
MRM1 [mitochondrial matrix]
(R-HSA-6793088)
0.527
4
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